PXD005769

PXD005769 is an original dataset announced via ProteomeXchange.

Title	Investigation of Plasmodium vivax trophozoite-schizont transition proteome
Description	The apicomplexan parasite Plasmodium vivax reportedly caused 13.8 million cases of vivax malaria in 2015. Much of the unique biology of this pathogen remains unknown. To expand our proteomics interrogation of the blood-stage interaction with its host animal model Saimiri boliviensis, we analyzed the proteome of infected host reticulocytes undergoing transition from the trophozoite to schizont stages. Two biological replicates analyzed using five database search engines identified 1923 P. vivax and 3188 S. boliviensis proteins. This project is part of the Malaria Host-Pathogen Interaction Center (MaHPIC) - a transdisciplinary malaria systems biology research program supported by an NIH/NIAID contract (# HHSN272201200031C; see http://www.systemsbiology.emory.edu). The MaHPIC generates many data types (e.g., clinical, parasitological, metabolomics, functional genomics, lipidomics, proteomics, immune response) and mathematical models, to iteratively test and develop hypotheses related to the complex host-parasite dynamics in the course of malaria in non-human primates, and metabolomics data via collaborations with investigators conducting clinical studies in malaria endemic countries, with the overarching goal of better understanding human disease, pathogenesis, and immunity. Within the MaHPIC, this project is known as 'Integral Supporting Project 05 (S05)'. Curation and maintenance of all data and metadata are the responsibility of the MaHPIC. This dataset was produced by Dave Anderson at SRI International.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:39:25.530.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jessica Kissinger
SpeciesList	scientific name: Saimiri boliviensis boliviensis; NCBI TaxID: 39432; scientific name: Plasmodium vivax Sal-1; NCBI TaxID: 126793;
ModificationList	L-methionine sulfoxide; L-methionine sulfone; L-cysteic acid (L-cysteine sulfonic acid); nitrated L-tyrosine
Instrument	LTQ Orbitrap XL ETD

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-23 06:38:16	ID requested
1	2017-08-07 08:14:34	announced
2	2017-09-12 02:32:35	announced	Updated publication reference for PubMed record(s): 28829774.
⏵ 3	2024-10-22 04:39:33	announced	2024-10-22: Updated project metadata.

10.1371/journal.pone.0182561;

Anderson DC, Lapp SA, Barnwell JW, Galinski MR, A large scale Plasmodium vivax- Saimiri boliviensis trophozoite-schizont transition proteome. PLoS One, 12(8):e0182561(2017) [pubmed]

ProteomeXchange project tag: Malaria Host-Pathogen Interaction Center (MaHPIC)

curator keyword: Biomedical

submitter keyword: LC MS/MS, MSGF, Sequest, Infected Red Blood Cell, Systems Biology, Malaria,Saimiri boliviensis, Mascot, Crux, MaHPIC, Plasmodium vivax, Reticulocyte, Schizont, Trophozoite, Andromeda

Mary Galinski
contact affiliation	Emory University
contact email	mahpic@emory.edu
lab head
Jessica Kissinger
contact affiliation	Institute of Bioinformatics, University of Georgia
contact email	mahpic-infodepo@uga.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD005769

PRIDE project URI

• PRIDE
  1. PXD005769
     1. Label: PRIDE project
     2. Name: Investigation of Plasmodium vivax trophozoite-schizont transition proteome