PXD005768

PXD005768 is an original dataset announced via ProteomeXchange.

Title	Proteogenomic characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling
Description	Hyperactivated mTOR signaling in the developing brain by mutation of TSC1 genes has multiple forms of pathology including tuberous sclerosis complex (TSC). To examine the downstream networks affected in the developing brain by hyperactivated mTOR signaling, we performed an integrated analysis of transcriptomic and proteomic analysis of forebrain of wild-type and TSC1/Emx1-Cre mouse. Our results provide novel and fundamental molecular bases for understanding hyperactivaed mTOR signaling-induced brain defects which can in turn facilitate identification of potential diagnostic markers and therapeutic targets for mTOR signaling-related neurological disorders.
HostingRepository	PRIDE
AnnounceDate	2018-08-16
AnnouncementXML	Submission_2018-08-16_06:31:35.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005768
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Minhyung Kim
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Carbamidomethyl; unknown modification
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-23 06:20:44	ID requested
⏵ 1	2018-08-16 06:31:36	announced

Shin J, Kim M, Jung HJ, Cha HL, Suh-Kim H, Ahn S, Jung J, Kim Y, Jun Y, Lee S, Hwang D, Kim J, Characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling by integrative analysis of transcriptomic and proteomic data. Sci Rep, 7(1):2826(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mouse, Brain, forebrain, LC-MSMS

Daehee Hwang
contact affiliation	Center for Plant Aging Research, Institute for Basic Science, and Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea
contact email	dhwang@dgist.ac.kr
lab head
Minhyung Kim
contact affiliation	Postech
contact email	hyung926@postech.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD005768

PRIDE project URI

• PRIDE
  1. PXD005768
     1. Label: PRIDE project
     2. Name: Proteogenomic characterization of developmental defects in the forebrain resulting from hyperactivated mTOR signaling