PXD005744

PXD005744 is an original dataset announced via ProteomeXchange.

Title	Purification and characterization of a novel allergenic walnut vicilin-like protein
Description	Walnuts are potent inducers of food allergic symptoms. So far, five allergens were identified, among those, Jug r 2 belonging to the vicilin family. Based on the identification of an IgE-reactive clone from a cDNA library in 1999 (Teuber et al.), the sequence fragment of Jug r 2 was determined. However, only limited data is known about the natural form of the protein. Therefore, this study aimed to purify and characterize the natural Jug r 2. During the study we identified another vicilin with both, higher sequence identity to vicilins from related species and IgE cross reactivity as compared to Jug r 2.
HostingRepository	PRIDE
AnnounceDate	2018-10-17
AnnouncementXML	Submission_2018-10-17_01:26:13.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005744
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Pawel Dubiela
SpeciesList	scientific name: Juglans regia (English walnut); NCBI TaxID: 51240;
ModificationList	Ammonia-loss; Amidated; GluGlu; Methyl; Cys->Dha; Phosphopantetheine; Oxidation; Ethanolyl; Delta:H(4)C(3); Phospho; Propionamide; Cation:Na; Deamidated; PyMIC; Trp->Oxolactone; Acetyl; MG-H1; SMA; Deoxy; Pyro-carbamidomethyl; Carboxymethyl; Formyl; HexNAc; Carbamyl; Lys->Allysine; Carbamidomethyl; Gln->pyro-Glu; PhosphoHexNAc; Guanidinyl; Glu->pyro-Glu; Dehydrated; 2-succinyl; Dioxidation; Benzoyl; Lipoyl; glycidamide
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-19 08:13:18	ID requested
⏵ 1	2018-10-17 01:26:15	announced

Dubiela P, Kabasser S, Smargiasso N, Geiselhart S, Bublin M, Hafner C, Mazzucchelli G, Hoffmann-Sommergruber K, Jug r 6 is the allergenic vicilin present in walnut responsible for IgE cross-reactivities to other tree nuts and seeds. Sci Rep, 8(1):11366(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: vicilin, walnut, food allergy

Pawel Dubiela
contact affiliation	Dept. of Pathophysiology and Allergy Research Medical University of Vienna AKH-EBO 3Q Waehringer Guertel 18-20 A-1090 Vienna, Austria
contact email	pawel.dubiela@meduniwien.ac.at
lab head
Pawel Dubiela
contact affiliation	Medical University of Vienna
contact email	pawel.dubiela@meduniwien.ac.at
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005744
     1. Label: PRIDE project
     2. Name: Purification and characterization of a novel allergenic walnut vicilin-like protein