PXD005698

PXD005698 is an original dataset announced via ProteomeXchange.

Title	Phosphoproteomics Profiling of Non-Small Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator
Description	Activation of protein phosphatase 2A (PP2A) is a promising anti-cancer therapeutic strategy given this tumor suppressor’s ability to coordinately downregulate multiple pathways involved with growth and proliferation.Here, we studied the global signaling response signature of a novel small molecule activator of PP2A (SMAP). Through an exploration of the global phosphoproteomicalterations of two KRAS mutated non-small cell lung cancer (NSCLC) cell lines (A549 and H358)in the context of PP2A activation, we sought to identify the pathway-level perturbations and uncover candidate proteins that are potentially key targets of SMAP regulation.
HostingRepository	PRIDE
AnnounceDate	2018-07-05
AnnouncementXML	Submission_2018-07-05_05:25:09.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005698
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Danica Wiredja
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Carbamidomethyl
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-12 03:18:33	ID requested
⏵ 1	2018-07-05 05:25:10	announced

Wiredja DD, Ayati M, Mazhar S, Sangodkar J, Maxwell S, Schlatzer D, Narla G, Koyut, ü, rk M, Chance MR, Phosphoproteomics Profiling of Nonsmall Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator. Proteomics, 17(22):(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: Label-free phosphoproteomics, functional network analysis, signaling response signatures, non-small cell lung cancer, phosphatase activation

Mark R. Chance
contact affiliation	Director, Center for Proteomics and Bioinformatics Charles W. and Iona A. Mathias Professor of Cancer Research
contact email	mrc16@case.edu
lab head
Danica Wiredja
contact affiliation	Case Western Reserve University
contact email	ddw34@case.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/07/PXD005698

PRIDE project URI

• PRIDE
  1. PXD005698
     1. Label: PRIDE project
     2. Name: Phosphoproteomics Profiling of Non-Small Cell Lung Cancer Cells Treated with a Novel Phosphatase Activator