PXD005693

PXD005693 is an original dataset announced via ProteomeXchange.

Title	Biomarkers discovery for Colorectal cancer
Description	Identification of early diagnostic and prognostic biomarkers measurable in liquid biopsies remains a major challenge in oncology today. OMICs technologies cannot be applied on clinically precious human material as this is required in its integrity for routine pathology investigation. Hence all OMICs discovery today is done on residual and not clinically relevant material. In the study, we present a novel, non-destructive, procedure named EXPEL, which uses rapid, pressure-assisted, interstitial fluid extrusion, allowing for full clinical pathology and OMICs analysis (proteins, metabolites, miRNA and DNA) on the same specimen. To demonstrate this we engage in a simultaneous biomarker discovery and routine diagnostic analysis of human colorectal cancer and liver metastases. Biomarkers discovered with EXPEL methodology can be readily detected in human sera, allowing for unprecedented translation to the clinic. EXPEL method enables for the first time both clinicians and scientist to explore identical, fresh, clinical material regardless of origin and size.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-10-26_10:41:07.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dominique Baiwir
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-12 02:44:27	ID requested
⏵ 1	2018-10-26 10:41:08	announced

Costanza B, Turtoi A, Bellahc, è, ne A, Hirano T, Peulen O, Blomme A, Hennequi, è, re V, Mutijima E, Boniver J, Meuwis MA, Josse C, Koopmansch B, Segers K, Yokobori T, Fahmy K, Thiry M, Coimbra C, Garbacki N, Colige A, Baiwir D, Bours V, Louis E, Detry O, Delvenne P, Nishiyama M, Castronovo V, Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget, 9(12):10665-10680(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: human, colon cancer, proteomic

Vincent Castronovo
contact affiliation	Metastases Research Laboratory, GIGA-CANCER, University of LIEGE, BELGIUM
contact email	vcastronovo@ulg.ac.be
lab head
Dominique Baiwir
contact affiliation	University of Liege
contact email	D.Baiwir@ulg.ac.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD005693

PRIDE project URI

• PRIDE
  1. PXD005693
     1. Label: PRIDE project
     2. Name: Biomarkers discovery for Colorectal cancer