PXD005692

PXD005692 is an original dataset announced via ProteomeXchange.

Title	Analysis of Human Breast Tumors by Integrated Proteotranscriptomics
Description	We generated large-scale proteome data for 65 human breast tumors and 53 paired adjacent non-cancerous tissue and performed an integrated proteotranscriptomic characterization. To our best knowledge, the study is one of the largest quantitative proteomic study of human breast tissues, including the analysis of 118 tissue samples from 65 patients with long-term survival outcomes. Our data show that protein expression describes a tumor biology that is only partly captured by the transcriptome, with mRNA abundance incompletely predicting protein abundance in tumors, and even less so in non-cancerous tissue. Furthermore, the tumor proteome described disease pathways and subgroups that were only partially captured by the tumor transcriptome.
HostingRepository	PRIDE
AnnounceDate	2018-12-04
AnnouncementXML	Submission_2019-02-12_08:15:31.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	wei tang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-12 01:42:45	ID requested
1	2018-12-04 09:06:39	announced
⏵ 2	2019-02-12 08:15:33	announced	Updated publication reference for PubMed record(s): 30501643.

Tang W, Zhou M, Dorsey TH, Prieto DA, Wang XW, Ruppin E, Veenstra TD, Ambs S, Integrated proteotranscriptomics of breast cancer reveals globally increased protein-mRNA concordance associated with subtypes and survival. Genome Med, 10(1):94(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: breast cancer proteomics

Wei Tang
contact affiliation	NCI/NIH
contact email	tangw3@mail.nih.gov
lab head
wei tang
contact affiliation	nih
contact email	tangw3@mail.nih.gov
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/12/PXD005692

PRIDE project URI

• PRIDE
  1. PXD005692
     1. Label: PRIDE project
     2. Name: Analysis of Human Breast Tumors by Integrated Proteotranscriptomics