PXD005649

PXD005649 is an original dataset announced via ProteomeXchange.

Title	C. elegans - starvation and UV
Description	DNA damage comprises a causal factor for aging and aging-associated diseases. Defects in genome maintenance pathways give rise to a variety of human congenital syndromes that are characterized by growth retardation, cancer susceptibility, and accelerated aging. The specific consequences of unrepaired DNA damage in human diseases are particularly apparent in syndromes caused by distinct nucleotide excision repair (NER) defects, however, with yet poorly understood genotype-phenotype correlations and highly complex disease phenotypes. We have established that the equivalent mutations in the simple metazoan Caenorhabditis elegans reflect the distinct outcomes of DNA repair defects and allow investigating the consequences of persistent DNA damage during animal development and aging. Here, we employed proteome, lipidome, and phosphoproteome analysis of NER-deficient animals in response to UV treatment in order to gain comprehensive insights into the full range of physiological adaptations to the presence of unrepaired DNA damage. We derive metabolic changes indicative of a tissue maintenance program and implicate an autophagy-mediated protoestatic response. We assign central roles for the IIS regulator DAF-2 and the EGF-signalling pathway in orchestrating this adaptive response to DNA damage. Our results provide new insights into the DNA damage responses in the organismal context.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:35:18.195.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hendrik Nolte
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-03 05:32:08	ID requested
1	2017-08-22 06:04:27	announced
2	2017-09-12 02:20:39	announced	Updated publication reference for PubMed record(s): 28854356.
⏵ 3	2024-10-22 04:35:26	announced	2024-10-22: Updated project metadata.

Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Kr, ü, ger M, Schumacher B, elegans. Cell Rep, 20(9):2026-2043(2017) [pubmed]

10.1016/j.celrep.2017.08.028;

submitter keyword: UV, phosphorpteomics and proteomics, Starvation,C. Elegans

Marcus Krüger
contact affiliation	CECAD Institut - University of Cologne Joseph-Stelzmann-Strasse 26 50931 Cologne Germany
contact email	marcus.krueger@uni-koeln.de
lab head
Hendrik Nolte
contact affiliation	Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
contact email	h.nolte@uni-koeln.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD005649

PRIDE project URI

• PRIDE
  1. PXD005649
     1. Label: PRIDE project
     2. Name: C. elegans - starvation and UV