⮝ Full datasets listing

PXD005649

PXD005649 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleC. elegans - starvation and UV
DescriptionDNA damage comprises a causal factor for aging and aging-associated diseases. Defects in genome maintenance pathways give rise to a variety of human congenital syndromes that are characterized by growth retardation, cancer susceptibility, and accelerated aging. The specific consequences of unrepaired DNA damage in human diseases are particularly apparent in syndromes caused by distinct nucleotide excision repair (NER) defects, however, with yet poorly understood genotype-phenotype correlations and highly complex disease phenotypes. We have established that the equivalent mutations in the simple metazoan Caenorhabditis elegans reflect the distinct outcomes of DNA repair defects and allow investigating the consequences of persistent DNA damage during animal development and aging. Here, we employed proteome, lipidome, and phosphoproteome analysis of NER-deficient animals in response to UV treatment in order to gain comprehensive insights into the full range of physiological adaptations to the presence of unrepaired DNA damage. We derive metabolic changes indicative of a tissue maintenance program and implicate an autophagy-mediated protoestatic response. We assign central roles for the IIS regulator DAF-2 and the EGF-signalling pathway in orchestrating this adaptive response to DNA damage. Our results provide new insights into the DNA damage responses in the organismal context.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:35:18.195.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHendrik Nolte
SpeciesList scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-01-03 05:32:08ID requested
12017-08-22 06:04:27announced
22017-09-12 02:20:39announcedUpdated publication reference for PubMed record(s): 28854356.
32024-10-22 04:35:26announced2024-10-22: Updated project metadata.
Publication List
Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Kr, ü, ger M, Schumacher B, elegans. Cell Rep, 20(9):2026-2043(2017) [pubmed]
10.1016/j.celrep.2017.08.028;
Keyword List
submitter keyword: UV, phosphorpteomics and proteomics, Starvation,C. Elegans
Contact List
Marcus Krüger
contact affiliationCECAD Institut - University of Cologne Joseph-Stelzmann-Strasse 26 50931 Cologne Germany
contact emailmarcus.krueger@uni-koeln.de
lab head
Hendrik Nolte
contact affiliationInstitute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD)
contact emailh.nolte@uni-koeln.de
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD005649
PRIDE project URI
Repository Record List
[ + ]