PXD005649 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | C. elegans - starvation and UV |
Description | DNA damage comprises a causal factor for aging and aging-associated diseases. Defects in genome maintenance pathways give rise to a variety of human congenital syndromes that are characterized by growth retardation, cancer susceptibility, and accelerated aging. The specific consequences of unrepaired DNA damage in human diseases are particularly apparent in syndromes caused by distinct nucleotide excision repair (NER) defects, however, with yet poorly understood genotype-phenotype correlations and highly complex disease phenotypes. We have established that the equivalent mutations in the simple metazoan Caenorhabditis elegans reflect the distinct outcomes of DNA repair defects and allow investigating the consequences of persistent DNA damage during animal development and aging. Here, we employed proteome, lipidome, and phosphoproteome analysis of NER-deficient animals in response to UV treatment in order to gain comprehensive insights into the full range of physiological adaptations to the presence of unrepaired DNA damage. We derive metabolic changes indicative of a tissue maintenance program and implicate an autophagy-mediated protoestatic response. We assign central roles for the IIS regulator DAF-2 and the EGF-signalling pathway in orchestrating this adaptive response to DNA damage. Our results provide new insights into the DNA damage responses in the organismal context. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:35:18.195.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hendrik Nolte |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | phosphorylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-01-03 05:32:08 | ID requested | |
1 | 2017-08-22 06:04:27 | announced | |
2 | 2017-09-12 02:20:39 | announced | Updated publication reference for PubMed record(s): 28854356. |
⏵ 3 | 2024-10-22 04:35:26 | announced | 2024-10-22: Updated project metadata. |
Publication List
Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Kr, ü, ger M, Schumacher B, elegans. Cell Rep, 20(9):2026-2043(2017) [pubmed] |
10.1016/j.celrep.2017.08.028; |
Keyword List
submitter keyword: UV, phosphorpteomics and proteomics, Starvation,C. Elegans |
Contact List
Marcus Krüger |
contact affiliation | CECAD Institut - University of Cologne Joseph-Stelzmann-Strasse 26 50931 Cologne Germany |
contact email | marcus.krueger@uni-koeln.de |
lab head | |
Hendrik Nolte |
contact affiliation | Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) |
contact email | h.nolte@uni-koeln.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005649
- Label: PRIDE project
- Name: C. elegans - starvation and UV