PXD005630

PXD005630 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Zebrafish synaptic proteome - Evolution of complexity in the zebrafish synapse proteome
Description	The proteome of human brain synapses is highly complex and mutated in over 130 diseases. This complexity arose from two whole genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases, however its synapse proteome is uncharacterised and whether the teleost-specific genome duplication (TSGD) influenced complexity is unknown. We report the first characterisation of the proteomes and ultrastructure of central synapses in zebrafish and analyse the importance of the TSGD. The TSGD increased overall synapse proteome complexity. The Post Synaptic Density (PSD) proteome of zebrafish had lower complexity than mammals and a highly conserved set of ~1000 proteins is shared across vertebrates. PSD ultrastructural features were also conserved. Lineage-specific proteome differences indicate vertebrate species evolved distinct synapse types and functions. The datasets are a resource for a wide range of studies and have important implications for the use of zebrafish in modelling human synaptic diseases.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:35:11.168.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mark Collins
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2017-01-02 06:52:44	ID requested
1	2017-03-06 05:36:19	announced
⏵ 2	2024-10-22 04:35:18	announced	2024-10-22: Updated project metadata.

Publication List

Bay, é, s À, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG, Evolution of complexity in the zebrafish synapse proteome. Nat Commun, 8():14613(2017) [pubmed]
10.1038/ncomms14613;

Bay, é, s À, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG, Evolution of complexity in the zebrafish synapse proteome. Nat Commun, 8():14613(2017) [pubmed]

10.1038/ncomms14613;

Keyword List

curator keyword: Biological
submitter keyword: Synapse,Zebrafish, Evolution

curator keyword: Biological

submitter keyword: Synapse,Zebrafish, Evolution

Contact List

Mark Collins
contact affiliation	University of Sheffield
contact email	mark.collins@shefield.ac.uk
lab head
Mark Collins
contact affiliation	University of Sheffield
contact email	mark.collins@sheffield.ac.uk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/03/PXD005630
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/03/PXD005630

PRIDE project URI

Repository Record List

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