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PXD005627

PXD005627 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSerine ADP-ribosylation depends on HPF1
DescriptionWe report that serine ADPr is strictly dependent on HPF1 (histone PARylation factor 1. Quantitative proteomics revealed that serine ADPr does not occur in cells lacking HPF1. We identified three endogenous serine ADPr sites are located on the PARP-1 automodification domain. Further identification of serine ADPr on hundreds of other targets indicates that serine ADPr is a widespread modification.
HostingRepositoryPRIDE
AnnounceDate2017-02-10
AnnouncementXMLSubmission_2017-02-14_03:33:54.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJuan Jose Bonfiglio
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListadenosine diphosphoribosyl (ADP-ribosyl) modified residue
InstrumentQ Exactive HF; Orbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-01-02 01:33:14ID requested
12017-02-10 02:42:14announced
22017-02-14 03:33:55announcedUpdated publication reference for PubMed record(s): 28190768.
Publication List
Bonfiglio JJ, Fontana P, Zhang Q, Colby T, Gibbs-Seymour I, Atanassov I, Bartlett E, Zaja R, Ahel I, Matic I, Serine ADP-Ribosylation Depends on HPF1. Mol Cell, 65(5):932-940.e6(2017) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: ADP-ribosylation
HPF1
PARP-1
PARP-2
histones
proteomics
Contact List
Ivan Matic
contact affiliationCECAD Research Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
contact emailimatic@age.mpg.de
lab head
Juan Jose Bonfiglio
contact affiliationCECAD Research Group, Max Planck Institute for Biology of Ageing, Cologne, Germany
contact emailjbonfiglio@age.mpg.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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