PXD005620

PXD005620 is an original dataset announced via ProteomeXchange.

Title	TGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells
Description	DNA mismatch repair-deficient colorectal tumors (CRC) frequently show coding microsatellite frameshift mutations in the MSI tumor driver Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) leading to cellular alteration of MSI tumor cells [Lee, J., Warnken, U., Schnölzer, M., Gebert, J. & Kopitz, J. (2015) Protein Sci. 24, 1686-94; Lee, J., Ballikaya, S., Schonig, K., Ball, C. R., Glimm, H., Kopitz, J. & Gebert, J. (2013) PloS one. 8, e57074]. Whether this receptor expression in MSI tumor cells also impacts the exosomal proteomic cargo of these cells is still unknown.
HostingRepository	PRIDE
AnnounceDate	2017-04-07
AnnouncementXML	Submission_2017-04-07_01:15:02.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005620
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Fabia Fricke
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Deamidated; Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2016-12-22 02:14:11	ID requested
⏵ 1	2017-04-07 01:15:03	announced

Fricke F, Lee J, Michalak M, Warnken U, Hausser I, Suarez-Carmona M, Halama N, Schn, ö, lzer M, Kopitz J, Gebert J, TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells. Cell Commun Signal, 15(1):14(2017) [pubmed]

submitter keyword: Exosomes, Proteomics, Transforming Growth Factor Beta Receptor Type 2, DNA Mismatch Repair Deficiency, Microsatellite Instability, Colorectal Cancer, LC-MSMS

Prof. Juergen Kopitz
contact affiliation	PI, Dept. Applied Tumor Biology, Institute of Pathology, University Hospital Heidelberg
contact email	juergen.kopitz@med.uni-heidelberg.de
lab head
Fabia Fricke
contact affiliation	PhD Student
contact email	f.fricke@dkfz-heidelberg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/04/PXD005620

PRIDE project URI

• PRIDE
  1. PXD005620
     1. Label: PRIDE project
     2. Name: TGFBR2-dependent Alterations of Exosomal Cargo in DNA Mismatch Repair-deficient HCT116 Colorectal Cancer Cells