PXD005592

PXD005592 is an original dataset announced via ProteomeXchange.

Title	Mouse EL4 Tumor Proteome Comparison via LC-MSMS
Description	The EL4 mouse tumor model is widely utilized within the field of oncology due to its ease of use and excellent response to chemotherapy, with tumors typically experiencing a reduction in mass of 70% following chemotherapy treatment with cyclophosphamide and etoposide for three days. As not much is known regarding the biochemical changes that result in these drastic reductions in tumor mass, we decided to analyze treated and untreated tumors using shotgun proteomics to identify the changes that occur in relative protein abundance following chemotherapeutic treatment, which will help determine the biological processes resulting in tumor death.
HostingRepository	PRIDE
AnnounceDate	2017-05-19
AnnouncementXML	Submission_2017-05-19_05:40:34.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Kramer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-12-19 02:16:05	ID requested
⏵ 1	2017-05-19 05:40:36	announced

Kramer DA, Eldeeb MA, Wuest M, Mercer J, Fahlman RP, Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo. Proteomics, 17(12):(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: Mouse Tumor, EL4 Lymphoma, Chemotherapy, Tumor Death, Proteomics

Richard P Fahlman
contact affiliation	Associate Professor, Department of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta
contact email	rfahlman@ualberta.ca
lab head
David Kramer
contact affiliation	University of Alberta Department of Biochemistry
contact email	dakramer@ualberta.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/05/PXD005592

PRIDE project URI

• PRIDE
  1. PXD005592
     1. Label: PRIDE project
     2. Name: Mouse EL4 Tumor Proteome Comparison via LC-MSMS