<< Full experiment listing


DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2017-05-19
  • AnnouncementXML: Submission_2017-05-19_05:40:34.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: David Kramer
  • Title: Mouse EL4 Tumor Proteome Comparison via LC-MSMS
  • Description: The EL4 mouse tumor model is widely utilized within the field of oncology due to its ease of use and excellent response to chemotherapy, with tumors typically experiencing a reduction in mass of 70% following chemotherapy treatment with cyclophosphamide and etoposide for three days. As not much is known regarding the biochemical changes that result in these drastic reductions in tumor mass, we decided to analyze treated and untreated tumors using shotgun proteomics to identify the changes that occur in relative protein abundance following chemotherapeutic treatment, which will help determine the biological processes resulting in tumor death.
  • SpeciesList: scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
  • ModificationList: monohydroxylated residue; iodoacetamide derivatized residue
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02016-12-19 02:16:05ID requested
12017-05-19 05:40:36announced

Publication List

  1. Kramer DA, Eldeeb MA, Wuest M, Mercer J, Fahlman RP, Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo. Proteomics, 17(12):(2017) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Mouse Tumor, EL4 Lymphoma, Chemotherapy, Tumor Death, Proteomics

Contact List

    Richard P Fahlman
    • contact affiliation: Associate Professor, Department of Biochemistry, Faculty of Medicine & Dentistry, University of Alberta
    • contact email: rfahlman@ualberta.ca
    • lab head:
    David Kramer
    • contact affiliation: University of Alberta Department of Biochemistry
    • contact email: dakramer@ualberta.ca
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
Subscribe to receive all new ProteomeXchange announcements!
If you have a question or comment about ProteomeXchange, please contact us!