PXD005560
PXD005560 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Identification of oxidative modifications of hemopexin and their physiological relevance |
| Description | This research provides novel insights into the underlying mechanism whereby the cyto- and neuro-protective heme binding protein hemopexin can be inactivated by reactive nitrogen species generated during the heme- and cytokine- driven inflammation that accompanies hemolysis. Nitration of amino acids is generally considered a selective and specific effect reflecting biological events. As we describe in a summary in the next paragraph, three tyrosine resides are preferentially targeted that reside in the heme binding site of apo-hemopexin. Hemopexin deficiency states develop in clinical sepsis and such modifications of hemopexin that we have identified and describe could also provide evidence-based guidance to physicians when heme toxicity is driving pathology to assess the timing and extent of hemopexin replenishment therapies and the patient responses to such treatment. |
| HostingRepository | MassIVE |
| AnnounceDate | 2017-07-19 |
| AnnouncementXML | Submission_2017-07-19_12:53:30.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Prof Ann Smith |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; scientific name: Rattus norvegicus; common name: Norway rat; NCBI TaxID: 10116; scientific name: Oryctolagus cuniculus; common name: rabbit; NCBI TaxID: 9986; |
| ModificationList | Nitro; (35)Cl labeled 3'-chlorotyrosine; (35)Cl labeled 3',5'-dichlorotyrosine; t-butyl ester (OtBu) and t-butyl (tBu); Carbamidomethyl |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2016-12-13 15:13:19 | ID requested | |
| ⏵ 1 | 2017-07-19 12:53:31 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: hemopexin, tyrosine nitration, mass spectrometry, proteomics, reactive oxygen species, covalent modification, reactive nitrogen species |
Contact List
| Dr. Ann Smith | |
|---|---|
| lab head | |
| Prof Ann Smith | |
| contact affiliation | University of Missouri-K.C. |
| contact email | smithan@umkc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080394 |
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