PXD005525

PXD005525 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of cisplatin exposure on the kidney cortex proteome and the effect of preconditioning
Description	Acute kidney injury and nephrotoxicity are important clinical side effects of cisplatin. Thus, the mechanisms of this disease, and potential treatment options are important to understand in their entity. Here, we analyzed the proteome of cisplatin induced acute kidney injury in a mouse model. Functionally we found that calorie restriction was able to completely blunt Cisplatin induced AKI, and hypoxia ameliorated cCisplatin induced AKI. To investigate the mechanism for this in high throughput, we performed label-free single-shot proteomic analyses of these kidneys.Acute kidney injury and nephrotoxicity are important clinical side effects of cisplatin. Thus, the mechanisms of this disease, and potential treatment options are important to understand in their entity. Here, we analyzed the proteome of cisplatin induced acute kidney injury in a mouse model. Functionally we found that calorie restriction was able to completely blunt Cisplatin induced AKI, and hypoxia ameliorated cCisplatin induced AKI. To investigate the mechanism for this in high throughput, we performed label-free single-shot proteomic analyses of these kidneys.
HostingRepository	PRIDE
AnnounceDate	2020-01-30
AnnouncementXML	Submission_2020-01-30_00:34:33.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Markus Rinschen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-12-08 01:03:12	ID requested
⏵ 1	2020-01-30 00:40:34	announced

Sp, ä, th MR, Bartram MP, Palacio-Escat N, Hoyer KJR, Debes C, Demir F, Schroeter CB, Mandel AM, Grundmann F, Ciarimboli G, Beyer A, Kizhakkedathu JN, Brodesser S, G, ö, bel H, Becker JU, Benzing T, Schermer B, H, ö, hne M, Burst V, Saez-Rodriguez J, Huesgen PF, M, ü, ller RU, Rinschen MM, The proteome microenvironment determines the protective effect of preconditioning in cisplatin-induced acute kidney injury. Kidney Int, 95(2):333-349(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: Kidney, cisplatin, caloric restriction,

Thomas Benzing
contact affiliation	University Hospital Cologne
contact email	thomas.benzing@uk-koeln.de
lab head
Markus Rinschen
contact affiliation	Kidney research center cologne
contact email	markus.rinschen@uk-koeln.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005525
     1. Label: PRIDE project
     2. Name: Proteomic analysis of cisplatin exposure on the kidney cortex proteome and the effect of preconditioning