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PXD005466

PXD005466 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSecretome cervical cancer LC-MS/MS
DescriptionThe molecular processes and proteomic markers leading to tumour development (TD) in cervical cancer (CC) are either unknown or only partially understood. TD affects metabolic and regulatory mechanisms that can be identified as proteomic changes. To identify which proteins are differentially expressed and to understand the mechanisms underlying cancer progression, we analysed the tumour proteome dynamics of CC cell lines. This analysis revealed two proteins that were up-regulated during TD: GSTM3 and GSTP1. These proteins are involved in cell maintenance, survival and stress responses during TD. We demonstrated that the GSTM3/HPV18 E7 interaction regulates stress adaptation. Furthermore, knockdown of GST proteins showed that they are involved in proliferation and evasion of apoptosis via the NF-kB and MAP kinase pathways during TD. These data indicate the critical role of GST proteins in the regulation and progression of cancer. Hence, we suggest GSTs as novel biomarkers and potential therapeutic targets for CC patients.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:34:11.544.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterALBERTO CHECA-ROJAS
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListiodoacetamide derivatized residue
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-11-30 01:37:02ID requested
12018-05-23 08:53:15announced
22024-10-22 04:34:12announced2024-10-22: Updated project metadata.
Publication List
10.18632/oncotarget.24796;
Checa-Rojas A, Delgadillo-Silva LF, Velasco-Herrera MDC, Andrade-Dom, í, nguez A, Gil J, Santill, á, n O, Lozano L, Toledo-Leyva A, Ram, í, rez-Torres A, Talamas-Rohana P, Encarnaci, ó, n-Guevara S, GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer. Oncotarget, 9(31):21696-21714(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: HSP70, secreted proteins, SiHa, HSP60, HeLa
Contact List
Sergio Encarnación Guevara
contact affiliationPrograma de Genómica Funcional de Procariontes, Centro de Ciencias Genómicas-UNAM. Av. Universidad s/n, Col. Chamilpa, Cuernavaca, Morelos. CP 62210. México.
contact emailencarnac@ccg.unam.mx
lab head
ALBERTO CHECA-ROJAS
contact affiliationUNAM
contact emailcheca.rojas@gmail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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