PXD005466

PXD005466 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Secretome cervical cancer LC-MS/MS
Description	The molecular processes and proteomic markers leading to tumour development (TD) in cervical cancer (CC) are either unknown or only partially understood. TD affects metabolic and regulatory mechanisms that can be identified as proteomic changes. To identify which proteins are differentially expressed and to understand the mechanisms underlying cancer progression, we analysed the tumour proteome dynamics of CC cell lines. This analysis revealed two proteins that were up-regulated during TD: GSTM3 and GSTP1. These proteins are involved in cell maintenance, survival and stress responses during TD. We demonstrated that the GSTM3/HPV18 E7 interaction regulates stress adaptation. Furthermore, knockdown of GST proteins showed that they are involved in proliferation and evasion of apoptosis via the NF-kB and MAP kinase pathways during TD. These data indicate the critical role of GST proteins in the regulation and progression of cancer. Hence, we suggest GSTs as novel biomarkers and potential therapeutic targets for CC patients.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:34:11.544.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	ALBERTO CHECA-ROJAS
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-30 01:37:02	ID requested
1	2018-05-23 08:53:15	announced
⏵ 2	2024-10-22 04:34:12	announced	2024-10-22: Updated project metadata.

Publication List

10.18632/oncotarget.24796;
Checa-Rojas A, Delgadillo-Silva LF, Velasco-Herrera MDC, Andrade-Dom, í, nguez A, Gil J, Santill, á, n O, Lozano L, Toledo-Leyva A, Ram, í, rez-Torres A, Talamas-Rohana P, Encarnaci, ó, n-Guevara S, GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer. Oncotarget, 9(31):21696-21714(2018) [pubmed]

10.18632/oncotarget.24796;

Checa-Rojas A, Delgadillo-Silva LF, Velasco-Herrera MDC, Andrade-Dom, í, nguez A, Gil J, Santill, á, n O, Lozano L, Toledo-Leyva A, Ram, í, rez-Torres A, Talamas-Rohana P, Encarnaci, ó, n-Guevara S, GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer. Oncotarget, 9(31):21696-21714(2018) [pubmed]

Keyword List

curator keyword: Biomedical
submitter keyword: HSP70, secreted proteins, SiHa, HSP60, HeLa

curator keyword: Biomedical

submitter keyword: HSP70, secreted proteins, SiHa, HSP60, HeLa

Contact List

Sergio Encarnación Guevara
contact affiliation	Programa de Genómica Funcional de Procariontes, Centro de Ciencias Genómicas-UNAM. Av. Universidad s/n, Col. Chamilpa, Cuernavaca, Morelos. CP 62210. México.
contact email	encarnac@ccg.unam.mx
lab head
ALBERTO CHECA-ROJAS
contact affiliation	UNAM
contact email	checa.rojas@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD005466
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/05/PXD005466

PRIDE project URI

Repository Record List

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