PXD005466 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Secretome cervical cancer LC-MS/MS |
Description | The molecular processes and proteomic markers leading to tumour development (TD) in cervical cancer (CC) are either unknown or only partially understood. TD affects metabolic and regulatory mechanisms that can be identified as proteomic changes. To identify which proteins are differentially expressed and to understand the mechanisms underlying cancer progression, we analysed the tumour proteome dynamics of CC cell lines. This analysis revealed two proteins that were up-regulated during TD: GSTM3 and GSTP1. These proteins are involved in cell maintenance, survival and stress responses during TD. We demonstrated that the GSTM3/HPV18 E7 interaction regulates stress adaptation. Furthermore, knockdown of GST proteins showed that they are involved in proliferation and evasion of apoptosis via the NF-kB and MAP kinase pathways during TD. These data indicate the critical role of GST proteins in the regulation and progression of cancer. Hence, we suggest GSTs as novel biomarkers and potential therapeutic targets for CC patients. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:34:11.544.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | ALBERTO CHECA-ROJAS |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-11-30 01:37:02 | ID requested | |
1 | 2018-05-23 08:53:15 | announced | |
⏵ 2 | 2024-10-22 04:34:12 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.18632/oncotarget.24796; |
Checa-Rojas A, Delgadillo-Silva LF, Velasco-Herrera MDC, Andrade-Dom, í, nguez A, Gil J, Santill, á, n O, Lozano L, Toledo-Leyva A, Ram, í, rez-Torres A, Talamas-Rohana P, Encarnaci, ó, n-Guevara S, GSTM3 and GSTP1: novel players driving tumor progression in cervical cancer. Oncotarget, 9(31):21696-21714(2018) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: HSP70, secreted proteins, SiHa, HSP60, HeLa |
Contact List
Sergio Encarnación Guevara |
contact affiliation | Programa de Genómica Funcional de Procariontes, Centro de Ciencias Genómicas-UNAM. Av. Universidad s/n, Col. Chamilpa, Cuernavaca, Morelos. CP 62210. México. |
contact email | encarnac@ccg.unam.mx |
lab head | |
ALBERTO CHECA-ROJAS |
contact affiliation | UNAM |
contact email | checa.rojas@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005466
- Label: PRIDE project
- Name: Secretome cervical cancer LC-MS/MS