PXD005460
PXD005460 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Ethological principles predict the neuropeptides co-opted to influence parenting |
| Description | Ethologists predicted that parental care evolves by modifying suitable behavioural precursors in the asocial ancestor. Traits such as nest building, defensive and aggressive behaviours, and potentially shared resources evolve to offspring protection and defence, and feeding. From this ethological principle, we further predicted that the evolved mechanistic changes would reside in genetic pathways underlying these behavioural precursors. While gene expression is difficult to detect for some molecules like neuropeptides, we tested our hypothesis by measuring abundance of neuropeptides in different behavioural states using LC-MS in female burying beetles, Nicrophorus vespilloides. Parenting in this species is extensive and complex as caring adults regurgitate food to begging, dependent offspring. We identified neuropeptides by sampling peptide abundance in female brains collected from three different behavioural states: solitary virgins, actively parenting, or post-parenting solitary adults. We identified 133 peptides belonging to 18 neuropeptides. Of these 18, eight differed in abundance in one or more state. We found increased abundance during parenting in seven of the eight. None of the identified neuropeptides have previously been associated with parental care, but all have known roles in predicted behavioural precursors of mating, resource defence, feeding, or social tolerance. Two, tachykinin and sulfakinin, influence multiple pathways. Our study supports the prediction that appropriate behavioural precursors are likely targets of selection during the evolution of parenting. Evolutionary principles predicted neuropeptides influencing social behaviour, and our results provide several new candidate neuropeptides underpinning parenting. |
| HostingRepository | MassIVE |
| AnnounceDate | 2016-11-29 |
| AnnouncementXML | Submission_2016-11-29_14:03:24.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Majors Badgett |
| SpeciesList | scientific name: Nicrophorus vespilloides; NCBI TaxID: 110193; |
| ModificationList | Amidated; Acetyl; Oxidation; Gln->pyro-Glu |
| Instrument | LTQ |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2016-11-29 13:56:10 | ID requested | |
| ⏵ 1 | 2016-11-29 14:03:25 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: beetle, neuropeptide, LC-MS/MS, Mascot, LTQ |
Contact List
| principal_investigator | |
|---|---|
| lab head | |
| Majors Badgett | |
| contact affiliation | University of Georgia |
| contact email | majorsbadgett@gmail.com |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080366 |
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