PXD005359

PXD005359 is an original dataset announced via ProteomeXchange.

Title	Effects of titanium dioxide (TiO2) nanoparticles (NPs) on endothelial cells
Description	The widespread commercial use of TiO2-NPs, such as in medical stents, has led to extensive investigations on their toxicity and biological impact but lacks a detailed study on their effects. Proteomics and transcriptomics are key methodologies to unravel cellular dynamics, macromolecular interactions and biological response to NP exposure through the protein or gene identification and quantification. We focus on integration of several Omics strategies that could offer a more complex understanding of the impact. In this study, our goal was to gain insight into the cellular response after the exposure to sublethal concentration of TiO2-ultra small nanoparticles (USNPs) and NPs by analyzing the modification on the genomic and proteomic expression in human microdermal endothelial cells (HMEC-1). We investigated the correlation between the NP size and the cellular response to the exposure. We evaluated if multiOmics approaches could thus reveal more extensive information on the potential cellular responses to NPs exposure.
HostingRepository	PRIDE
AnnounceDate	2019-01-16
AnnouncementXML	Submission_2019-01-16_02:23:43.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005359
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jacob Kuruvilla
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Phospho; Dehydrated; Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-15 08:20:23	ID requested
⏵ 1	2019-01-16 02:23:45	announced

Kuruvilla J, Bayat N, Cristobal S, Proteomic Analysis of Endothelial Cells Exposed to Ultrasmall Nanoparticles Reveals Disruption in Paracellular and Transcellular Transport. Proteomics, 19(5):e1800228(2019) [pubmed]

curator keyword: Biomedical

submitter keyword: titanium dioxide, nanoparticles, endothelial cells

Susana Cristobal
contact affiliation	Department of Clinical and Experimental Medicine
contact email	susana.cristobal@liu.se
lab head
Jacob Kuruvilla
contact affiliation	Linkoping University
contact email	jacob.kuruvilla@liu.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005359
     1. Label: PRIDE project
     2. Name: Effects of titanium dioxide (TiO2) nanoparticles (NPs) on endothelial cells