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PXD005343 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteome of Tcte1 deficient mouse sperm
DescriptionSperm motility is one of the most important determinants of male fertility. Elucidating the different expression proteins of nomal and asthenospermia spermatozoa should advance our understanding of the underlying molecular mechanisms. Tcte1 null mouse sperm reduced motility and failed to display the forward progressive motile. With tandem mass tag (TMT) labeling and mass spectrometry analysis´╝î 3697 proteins were quantified from Widetype and Tcte1 deficient mouse spermatozoa. Of these proteins, 447 were found to be different expression proteins (DEPs), including 398 proteins down regulated (DDEPs, 89%) and only 49 proteins up regulated.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTao Zhou
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-11-14 05:25:06ID requested
12018-02-09 09:02:03announced
Publication List
Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M, Matzuk MM, Liu M, TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Proc Natl Acad Sci U S A, 114(27):E5370-E5378(2017) [pubmed]
Keyword List
submitter keyword: mouse, sperm, Tcte1, TMT6
Contact List
Jiahao Sha
contact affiliationState Key Laboratory of Reproductive Medicine, Nanjing Medical University
contact emailshajh@njmu.edu.cn
lab head
Tao Zhou
contact affiliationCentral Laboratory, Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University
contact emailzhoutao@njmu.edu.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
PRIDE project URI
Repository Record List
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