PXD005333

PXD005333 is an original dataset announced via ProteomeXchange.

Title	Delta-like ligand 4-Notch signaling inhibition regulates pancreatic islet function and insulin secretion
Description	Dll4-Notch signaling is required for cell fate decisions and neoplasias. However, emerging evidence suggests a role for Dll4-Notch signaling in metabolic and immune diseases. To date, there is no evidence of a direct effect of Dll4-Notch signaling inhibition on pancreatic islet function and insulin secretion.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:16:34.923.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antigoni Manousopoulou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue; deaminated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-14 01:59:41	ID requested
1	2018-08-13 09:22:26	announced
2	2019-02-12 08:12:31	announced	Updated publication reference for PubMed record(s): 29386132.
⏵ 3	2024-10-22 04:16:35	announced	2024-10-22: Updated project metadata.

Billiard F, Karaliota S, Wang B, Stellas D, Serafimidis I, Manousopoulou A, Koutmani Y, Ninou E, Golubov J, DaNave A, Tsakanikas P, Xin Y, Zhang W, Sleeman M, Yancopoulos GD, Murphy AJ, Garbis SD, Karalis K, Skokos D, Delta-like Ligand-4-Notch Signaling Inhibition Regulates Pancreatic Islet Function and Insulin Secretion. Cell Rep, 22(4):895-904(2018) [pubmed]

10.1016/j.celrep.2017.12.076;

curator keyword: Biomedical

submitter keyword: GSIs, Dll4,diabetes

Spiros D. Garbis
contact affiliation	University of Southampton
contact email	S.D.Garbis@soton.ac.uk
lab head
Antigoni Manousopoulou
contact affiliation	Proteas Bioanalytics Inc.
contact email	Antigoni.Manousopoulou@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD005333

PRIDE project URI

• PRIDE
  1. PXD005333
     1. Label: PRIDE project
     2. Name: Delta-like ligand 4-Notch signaling inhibition regulates pancreatic islet function and insulin secretion