PXD005322

PXD005322 is an original dataset announced via ProteomeXchange.

Title	Proteomic comparison of tissue engineered tendon constructs derived young and old cells
Description	Tendon injuries can occur due to sports related incidents, as a result of trauma to overuse or during disease or ageing. Tissue engineering can offer great potential in the treatment of a tendon injury. The preferred cell source is autologous in order to reduce immune response in the treated individual. However, in elderly patients age-related changes in metabolism of the implanted cells may affect results of such therapy. In this study the effect of donor age on synthetic activity of cells used for creation of tendon tissue-engineered constructs was investigated by using label-free proteomic comparison.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-10-26_13:06:16.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005322
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yalda Ashraf
SpeciesList	scientific name: Equus caballus (Horse); NCBI TaxID: 9796;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-11 02:28:44	ID requested
⏵ 1	2018-10-26 13:06:17	announced

Turlo AJ, Ashraf Kharaz Y, Clegg PD, Anderson J, Peffers MJ, Donor age affects proteome composition of tenocyte-derived engineered tendon. BMC Biotechnol, 18(1):2(2018) [pubmed]

curator keyword: Biological

submitter keyword: tendon, tissue engineered constructs, young and old, LC-MS/MS

Dr Mandy Peffers
contact affiliation	Institute of Ageing and Chronic Disease, Musculoskeletal Biology, University of Liverpool
contact email	peffs@liverpool.ac.uk
lab head
Yalda Ashraf
contact affiliation	University of Liverpool
contact email	yalda@liverpool.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005322
     1. Label: PRIDE project
     2. Name: Proteomic comparison of tissue engineered tendon constructs derived young and old cells