PXD005317

PXD005317 is an original dataset announced via ProteomeXchange.

Title	The diurnal liver acetylome is regulated by circadian and feeding rhythms-orchestrated deacetylation - total mouse liver extract
Description	Acetylation of lysine is involved in various biological processes and is considered as a key reversible post-translational modification (PTM) in the regulation of gene expression, enzyme activity, protein-protein interaction, and subcellular localization. This PTM is therefore highly relevant in the context of circadian biology but its characterization at the genome wide scale and its clock-dependent or -independent regulation is still poorly characterized. Here we used in vivo stable isotope labeling by amino acids (SILAC) coupled with an enrichment of acetylated-lysine-containing peptides to provide a comprehensive and rhythmic acetylome map of the liver.
HostingRepository	PRIDE
AnnounceDate	2017-08-02
AnnouncementXML	Submission_2017-08-22_03:24:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Loïc Dayon
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	6x(13)C labeled residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-11 00:21:05	ID requested
1	2017-08-02 09:48:31	announced
⏵ 2	2017-08-22 03:24:19	announced	Updated publication reference for PubMed record(s): 28813682.

Mauvoisin D, Atger F, Dayon L, N, ú, ñ, ez Galindo A, Wang J, Martin E, Da Silva L, Montoliu I, Collino S, Martin FP, Ratajczak J, Cant, ó C, Kussmann M, Naef F, Gachon F, Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. Cell Rep, 20(7):1729-1743(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Mouse, Liver, Circadian clock, Acetylation, Acetylome, Metabolism, SIRT3, NAD+

Frédéric Gachon
contact affiliation	Diabetes and Circadian Rhythms Department, Nestlé Institute of Health Sciences, CH-1015 Lausanne, Switzerland
contact email	frederic.gachon@rd.nestle.com
lab head
Loïc Dayon
contact affiliation	Nestlé Institute of Health Sciences SA
contact email	loic.dayon@rd.nestle.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD005317

PRIDE project URI

• PRIDE
  1. PXD005317
     1. Label: PRIDE project
     2. Name: The diurnal liver acetylome is regulated by circadian and feeding rhythms-orchestrated deacetylation - total mouse liver extract