PXD005314

PXD005314 is an original dataset announced via ProteomeXchange.

Title	Human cerebrospinal fluid proteoform profiling
Description	. In this study, we have investigated the capacities of last-generation Ultra-High Resolution Q-Tof systems to deal with high complexity intact protein samples, have developed the tools to process the intact protein data in an existing label-free quantification pipeline, and have evaluated the approach on a cohort of patients suffering from neurodegenerative disease in a proof-of concept study. Several proteoforms have been pointed out for their capacity to distinguish Alzheimer disease patients from patients suffering from other neurodegenerative disease and have been characterized.
HostingRepository	PRIDE
AnnounceDate	2018-04-05
AnnouncementXML	Submission_2018-04-05_05:33:29.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Pierre-Olivier SCHMIT
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	amidated residue; monohydroxylated residue
Instrument	impact II

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-11 00:17:29	ID requested
⏵ 1	2018-04-05 05:33:30	announced

Schmit PO, Vialaret J, Wessels HJCT, van Gool AJ, Lehmann S, Gabelle A, Wood J, Bern M, Paape R, Suckau D, Kruppa G, Hirtz C, Towards a routine application of Top-Down approaches for label-free discovery workflows. J Proteomics, 175():12-26(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: CSF, proteoforms, Alzheimer

Dr. Christophe Hirtz
contact affiliation	Clinical Proteomic Platform CHU de Montpellier - Hôpital St. Eloi Institute of Regenerative Medicine - Biotherapy - IRMB 80, av A. Fliche, 34295 Montpellier Cedex 5
contact email	c-hirtz@chu-montpellier.fr
lab head
Pierre-Olivier SCHMIT
contact affiliation	Bruker Daltonique S.A
contact email	pierre-olivier.schmit@bruker.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD005314

PRIDE project URI

• PRIDE
  1. PXD005314
     1. Label: PRIDE project
     2. Name: Human cerebrospinal fluid proteoform profiling