PXD005295

PXD005295 is an original dataset announced via ProteomeXchange.

Title	N-Linked Glycoprotein Profiles of Human Breast Basal Malignant Cell Lines
Description	Secreted proteins and transmembrane proteins with extracellular domains are frequently glycosylated; this group of proteins includes those that participate in the various intercellular junctions and signaling pathways of an epithelium. In this study we characterized the differences in glycoprotein expression between claudin-low and other breast cell lines using a dataset of 26 breast cell lines in which the glycoproteins were identified and quantitated by liquid chromatography/ tandem mass spectrometry. Our goals are to characterize the glycoproteome of a set of claudin-low lines, compare them to basal, luminal and non-malignant cells and to identify drugs that may be especially effective on these cell lines. These nine basal malignant breast cells (HCC1143, HCC1395, HCC1937, HCC1954, HCC38, HCC70, MDAMB468, SUM149PT and SUM229PE) data are a part of 26 breast cell lines we analyzed.
HostingRepository	PRIDE
AnnounceDate	2017-03-27
AnnouncementXML	Submission_2017-03-27_02:04:46.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD005295
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ten-Yang Yen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Asn->Asp; Deamidated; Oxidation; Carbamidomethyl; Deamidated:18O(1)
Instrument	LTQ; Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-11-08 05:12:48	ID requested
⏵ 1	2017-03-27 02:04:47	announced

Yen TY, Bowen S, Yen R, Piryatinska A, Macher BA, Timpe LC, Glycoproteins in Claudin-Low Breast Cancer Cell Lines Have a Unique Expression Profile. J Proteome Res, 16(4):1391-1400(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Human, Breast, Cell Line, Basal, Glycoprotein, N-Linked, LC-MSMS

Ten-Yang Yen
contact affiliation	Mass Spectrometry Facility, Department of Chemistry and Biochemistry, San Francisco State University, USA
contact email	ryen@sfsu.edu
lab head
Ten-Yang Yen
contact affiliation	San Francisco State University-USA
contact email	ryen@sfsu.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005295
     1. Label: PRIDE project
     2. Name: N-Linked Glycoprotein Profiles of Human Breast Basal Malignant Cell Lines