PXD005255 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Bacteroides fragilis outer membrane vesicles |
| Description | Number of publications show that intestinal microflora vesicles secretion is essential for the maintaining homeostasis. Conducted comprehensive genomic, transcriptomic and proteomic studies of vesicles determine the nature and the basic mechanisms of bacterial influence to the host. The role of the vesicles to a greater extent is defined as carriers of virulence factors or enzymes determining the nutritional function. In addition some bacterial vesicles have a special mission. B.fragilis vesicles are providing anti-inflammatory effect on the colon immune cells. However there is no information about possible role of vesicles secreted by ETBF, contributing bowel disease development and colon cancer. To determine possible effects of ETBF vesicles to the host compared with NTBF, we performed comprehensive proteome and for the first time metabolome analysis and reconstructed pathways for vesicles of both strains with subsequent confirmation of the activity of one of the main pathway by fluxome analysis. A detailed analysis of the vesicles allowed us to discover a new quality of ETBF vesicles as intelligent systems capable of absorbing and processing of exogenous substrates. We believe that this property allows them to maintain stability for a long time and implement mechanisms of pathogenicity. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-10-22 |
| AnnouncementXML | Submission_2024-10-22_04:33:46.382.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD005255 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Ivan Butenko |
| SpeciesList | scientific name: Bacteroides fragilis (strain ATCC 25285 / NCTC 9343); NCBI TaxID: 272559; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2016-11-02 03:21:38 | ID requested | |
| 1 | 2017-11-13 00:28:37 | announced | |
| ⏵ 2 | 2024-10-22 04:33:48 | announced | 2024-10-22: Updated project metadata. |
Publication List
| Zakharzhevskaya NB, Vanyushkina AA, Altukhov IA, Shavarda AL, Butenko IO, Rakitina DV, Nikitina AS, Manolov AI, Egorova AN, Kulikov EE, Vishnyakov IE, Fisunov GY, Govorun VM, Outer membrane vesicles secreted by pathogenic and nonpathogenic Bacteroides fragilis represent different metabolic activities. Sci Rep, 7(1):5008(2017) [pubmed] |
| 10.6019/PXD005255; |
| 10.1038/s41598-017-05264-6; |
Keyword List
| curator keyword: Biological, Biomedical |
| submitter keyword: proteomics,Bacteroides fragilis, vesicles |
Contact List
| Gleb Fisunov |
|---|
| contact affiliation | Laboratory of proteomic analysis of Scientific Research Institute of Physical-Chemical Medicine, Moscow, Russia |
| contact email | herr.romanoff@gmail.com |
| lab head | |
| Ivan Butenko |
|---|
| contact affiliation | Scientific Research Institute for Systems Biology and Medicine, Moscow, Russian Federation |
| contact email | ivan.butenko@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/11/PXD005255 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005255
- Label: PRIDE project
- Name: Bacteroides fragilis outer membrane vesicles
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