PXD005216

PXD005216 is an original dataset announced via ProteomeXchange.

Title	The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention
Description	The nutritional intervention program “DiOGenes” focuses on how obesity can be prevented and treated from a dietary perspective. We have generated differential plasma proteome profiles in the DiOGenes cohort to identify proteins associated with weight loss and maintenance and explore their relation to body mass index, fat mass, insulin resistance and sensitivity. Relative protein quantification was obtained at baseline and after combined weight loss/maintenance phases using isobaric tagging and MS/MS. 473 subjects were measured at baseline and end of the intervention; 183 proteins were quantified in more than 70% of the plasma samples. The MS-based proteomic analysis of this large cohort of non-diabetic overweight and obese individuals concomitantly identified known and novel proteins associated with weight loss and maintenance. ClinicalTrials.gov Identifier: NCT00390637
HostingRepository	PRIDE
AnnounceDate	2017-04-04
AnnouncementXML	Submission_2018-11-26_00:48:47.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Loïc Dayon
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-10-24 06:13:16	ID requested
1	2017-04-04 02:12:40	announced
⏵ 2	2018-11-26 00:48:49	announced	Updated publication reference for PubMed record(s): 28371297, 30451909.

Oller Moreno S, Cominetti O, N, ú, ñ, ez Galindo A, Irincheeva I, Corth, é, sy J, Astrup A, Saris WHM, Hager J, Kussmann M, Dayon L, The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention. Proteomics Clin Appl, 12(1):(2018) [pubmed]

Cominetti O, N, ú, ñ, ez Galindo A, Corth, é, sy J, Valsesia A, Irincheeva I, Kussmann M, Saris WHM, Astrup A, McPherson R, Harper ME, Dent R, Hager J, Dayon L, Obesity shows preserved plasma proteome in large independent clinical cohorts. Sci Rep, 8(1):16981(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Plasma, Human, Obesity, Diabetes, Biomarker, Proteomics, Mass spectrometry

Loïc Dayon
contact affiliation	Proteomics Team, Nestlé Institute of Health Sciences, Lausanne, Switzerland
contact email	loic.dayon@rd.nestle.com
lab head
Loïc Dayon
contact affiliation	Nestlé Institute of Health Sciences SA
contact email	loic.dayon@rd.nestle.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/04/PXD005216

PRIDE project URI

• PRIDE
  1. PXD005216
     1. Label: PRIDE project
     2. Name: The differential plasma proteome of obese and overweight individuals undergoing a nutritional weight loss and maintenance intervention