PXD005178

PXD005178 is an original dataset announced via ProteomeXchange.

Title	Oligopeptide Importers AliC and AliD of Nonencapsulated Streptococcus pneumoniae Facilitate Mucosal Infections and Mediate Persistence during Invasive Disease
Description	Nonencapsulated Streptococcus pneumoniae (NESp) is an emerging human pathogen that colonizes the nasopharynx and is associated with noninvasive disease such as otitis media (OM), conjunctivitis, and nonbacteremic pneumonia. For decades, expression of a polysaccharide capsule appeared to be necessary for establishment of colonization and development of invasive pneumococcal disease (IPD). Accordingly, the currently licensed pneumococcal vaccines target the polysaccharide capsule. However, NESp expressing the novel oligopeptide importer proteins AliC and AliD have been isolated during IPD. Our study reveals that NESp expressing AliC and AliD have intensified virulence compared to isogenic mutants, and we provide insight about how this pneumococcal population has become associated with IPD. Our data demonstrates that AliC and AliD enhance murine nasopharyngeal colonization and are required for OM in a chinchilla model. Furthermore, AliC and AliD increase pneumococcal survival in chinchilla whole blood and decrease deposition of human C3b on the bacterial surface. As NESp become an increasing threat to public health, our study exposes specific virulence factors to possibly target for a broadened prevention of IPD through vaccination.
HostingRepository	PRIDE
AnnounceDate	2018-01-22
AnnouncementXML	Submission_2018-01-22_04:21:03.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ken Pendarvis
SpeciesList	scientific name: Streptococcus pneumoniae; NCBI TaxID: 1313;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-10-18 01:23:22	ID requested
⏵ 1	2018-01-22 04:21:04	announced

Bradshaw JL, Pipkins HR, Keller LE, Pendarvis JK, McDaniel LS, Are Enhanced by Oligopeptide Binding Proteins AliC and AliD. mBio, 9(1):(2018) [pubmed]

curator keyword: Biomedical

submitter keyword: Streptocuccus pneumoniae pneumococcus MHZ41 LTQ Velos Linear Trap

Larry S. McDaniel
contact affiliation	Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, United States of America
contact email	lmcdaniel@umc.edu
lab head
Ken Pendarvis
contact affiliation	Veterinary Science and Microbiology
contact email	jkpendarvis@email.arizona.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD005178
     1. Label: PRIDE project
     2. Name: Oligopeptide Importers AliC and AliD of Nonencapsulated Streptococcus pneumoniae Facilitate Mucosal Infections and Mediate Persistence during Invasive Disease