PXD005144

PXD005144 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Chronic pancreatitis vs pancreatic cancer LC-MS
Description	Age-standardized incidence rates for pancreatic cancer (PC) in men have increased by 25% from 1957 to 2011 in Finland. The average age of diagnosis for PC is 69 years in Nordic males, whereas the average age of diagnosis of chronic pancreatitis (CP) is 40-50 years, but the cases overlap in age. By radiology the evaluation of a pancreatic mass, i.e. the differential diagnosis between CP and PC is often difficult. Preoperative needle biopsies are difficult to obtain and are demanding to interpret. New blood based biomarkers are needed. The accuracy of the only established biomarker for PC, CA 19-9 is rather poor in differentiating between benign and malignant mass of the pancreas. In this study, we have performed mass spectrometry HDMSE analysis of serum samples from patients with chronic pancreatitis and pancreatic cancer. We have quantified 652 proteins and performed detailed statistical analysis such as principal component analysis, orthogonal partial least square discriminant analysis and receiver operating curve analysis.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:33:16.651.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-10-13 02:27:01	ID requested
1	2017-06-09 04:09:35	announced
⏵ 2	2024-10-22 04:33:24	announced	2024-10-22: Updated project metadata.

Publication List

Saraswat M, Joenv, ä, ä, r, ä S, Sepp, ä, nen H, Mustonen H, Haglund C, Renkonen R, Comparative proteomic profiling of the serum differentiates pancreatic cancer from chronic pancreatitis. Cancer Med, 6(7):1738-1751(2017) [pubmed]
10.1002/cam4.1107;

Saraswat M, Joenv, ä, ä, r, ä S, Sepp, ä, nen H, Mustonen H, Haglund C, Renkonen R, Comparative proteomic profiling of the serum differentiates pancreatic cancer from chronic pancreatitis. Cancer Med, 6(7):1738-1751(2017) [pubmed]

10.1002/cam4.1107;

Keyword List

curator keyword: Biomedical
submitter keyword: Multivariate data analysis, LC-MS,Chronic pancreatitis, pancreatic ductal adenocarcinoma, label-free qunatification, pancreatic cancer

curator keyword: Biomedical

submitter keyword: Multivariate data analysis, LC-MS,Chronic pancreatitis, pancreatic ductal adenocarcinoma, label-free qunatification, pancreatic cancer

Contact List

Risto Renkonen
contact affiliation	Transplantation Laboratory, Haartman Institute, University of Helsinki, Finland
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/06/PXD005144

PRIDE project URI

Repository Record List

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