PXD005139 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Podocyte degradomics |
Description | Regulated intracellular proteolysis is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. Altered proteolytic substrate turnover has been associated with various glomerular diseases ranging from diabetic nephropathy to focal and segmental glomerulosclerosis. However, thus far it has not been possible to systematically identify proteolytically cleaved proteins although some of the proteases have been characterized. Here we applied TAILS to map N-termini in the mouse glomeruli proteome and to determine and quantify N termini in podocyte cell cultures challenged with PAN. |
HostingRepository | PRIDE |
AnnounceDate | 2017-07-20 |
AnnouncementXML | Submission_2017-07-21_01:29:07.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Pitter Huesgen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-10-12 23:58:47 | ID requested | |
1 | 2017-07-20 04:14:40 | announced | |
⏵ 2 | 2017-07-21 01:29:08 | announced | Updated publication reference for PubMed record(s): 28724775. |
Publication List
Rinschen MM, Hoppe AK, Grahammer F, Kann M, V, ö, lker LA, Schurek EM, Binz J, H, ö, hne M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF, Benzing T, N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton. J Am Soc Nephrol, 28(10):2867-2878(2017) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Mouse, kidney, glomeruli, TAILS |
Contact List
Pitter F. Huesgen |
contact affiliation | ZEA-3 Analytics Forschungszentrum Juelich Wilhelm-Johnen-Str D-52425 Juelich Germany |
contact email | p.huesgen@fz-juelich.de |
lab head | |
Pitter Huesgen |
contact affiliation | Forschungszentrum Jülich |
contact email | p.huesgen@fz-juelich.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD005139
- Label: PRIDE project
- Name: Podocyte degradomics