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PXD005116

PXD005116 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleComparative Tissue Proteomics for the Diagnosis of Indeterminate Pulmonary Nodules
DescriptionWe identified candidate protein biomarkers to distinguish lung adenocarcinomas from benign nodules. We employed shotgun proteomics using a multidimensional peptide separation approach coupled to tandem mass spectrometry (LC-MS/MS) to characterize proteomes of a collection of 34 benign lung nodules. The benign lung nodule inventories were compared to inventories from early stage lung adenocarcinomas, from 24 patients with non-adjuvant treatment following the resection, and to inventories from normal tissue collected from 10 patients as bronchial and alveolar epithelium to identify biomarkers.We developed PRM assays to quantify a subset of 43 candidate biomarker proteins via 170 tryptic peptides in a single LC-PRM-MS run using a validation cohort of 20 benign nodules, 20 adenocarcinoma, and 20 normal lung tissues.
HostingRepositoryMassIVE
AnnounceDate2016-11-04
AnnouncementXMLSubmission_2016-11-04_09:35:17.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRobbert Slebos
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ XL; LTQ Velos; LTQ Orbitrap XL; Q Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-10-09 17:16:39ID requested
12016-11-04 09:35:18announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Granuloma, Shotgun Proteomics, Parallel Reaction Monitoring, Adenocarcinoma
Contact List
Daniel Liebler
lab head
Robbert Slebos
contact affiliationMoffitt
contact emailrobbert.slebos@moffitt.org
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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