PXD005116

PXD005116 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Comparative Tissue Proteomics for the Diagnosis of Indeterminate Pulmonary Nodules
Description	We identified candidate protein biomarkers to distinguish lung adenocarcinomas from benign nodules. We employed shotgun proteomics using a multidimensional peptide separation approach coupled to tandem mass spectrometry (LC-MS/MS) to characterize proteomes of a collection of 34 benign lung nodules. The benign lung nodule inventories were compared to inventories from early stage lung adenocarcinomas, from 24 patients with non-adjuvant treatment following the resection, and to inventories from normal tissue collected from 10 patients as bronchial and alveolar epithelium to identify biomarkers.We developed PRM assays to quantify a subset of 43 candidate biomarker proteins via 170 tryptic peptides in a single LC-PRM-MS run using a validation cohort of 20 benign nodules, 20 adenocarcinoma, and 20 normal lung tissues.
HostingRepository	MassIVE
AnnounceDate	2016-11-04
AnnouncementXML	Submission_2016-11-04_09:35:17.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Robbert Slebos
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ XL; LTQ Velos; LTQ Orbitrap XL; Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-10-09 17:16:39	ID requested
⏵ 1	2016-11-04 09:35:18	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Granuloma, Shotgun Proteomics, Parallel Reaction Monitoring, Adenocarcinoma

submitter keyword: Granuloma, Shotgun Proteomics, Parallel Reaction Monitoring, Adenocarcinoma

Contact List

Daniel Liebler
lab head
Robbert Slebos
contact affiliation	Moffitt
contact email	robbert.slebos@moffitt.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080236