PXD005116
PXD005116 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative Tissue Proteomics for the Diagnosis of Indeterminate Pulmonary Nodules |
Description | We identified candidate protein biomarkers to distinguish lung adenocarcinomas from benign nodules. We employed shotgun proteomics using a multidimensional peptide separation approach coupled to tandem mass spectrometry (LC-MS/MS) to characterize proteomes of a collection of 34 benign lung nodules. The benign lung nodule inventories were compared to inventories from early stage lung adenocarcinomas, from 24 patients with non-adjuvant treatment following the resection, and to inventories from normal tissue collected from 10 patients as bronchial and alveolar epithelium to identify biomarkers.We developed PRM assays to quantify a subset of 43 candidate biomarker proteins via 170 tryptic peptides in a single LC-PRM-MS run using a validation cohort of 20 benign nodules, 20 adenocarcinoma, and 20 normal lung tissues. |
HostingRepository | MassIVE |
AnnounceDate | 2016-11-04 |
AnnouncementXML | Submission_2016-11-04_09:35:17.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Robbert Slebos |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ XL; LTQ Velos; LTQ Orbitrap XL; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2016-10-09 17:16:39 | ID requested | |
⏵ 1 | 2016-11-04 09:35:18 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Granuloma, Shotgun Proteomics, Parallel Reaction Monitoring, Adenocarcinoma |
Contact List
Daniel Liebler | |
---|---|
lab head | |
Robbert Slebos | |
contact affiliation | Moffitt |
contact email | robbert.slebos@moffitt.org |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080236 |