PXD005091

PXD005091 is an original dataset announced via ProteomeXchange.

Title	Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-virus interference phenomenon
Description	Cellular models have provided significant advances on molecular bases of bipartite interactions between either an arbovirus or a bacterial symbiont with a given arthropod vector. However, although an interference phenomenon was evidenced in tripartite interaction arbovirus-symbiont-mosquito vector very little is known regarding the mechanisms involved. Using large-scale proteome profiling, we characterized proteins differentially expressed in Aedes albopictus cells infected by the symbiotic bacterium Wolbachia and the Chikungunya virus (CHIKV). These proteins were mostly related to cellular processes involved in glycolysis process, protein metabolism, translation and amino acid metabolism. The presence of Wolbachia impacted significantly the protein profiles, including sequestration of proteins such as structural polyprotein and capsid viral proteins that may affect replication and assembly of CHIKV in cellulo. This study provides insights into the molecular pathways involved in the tripartite interaction mosquito-Wolbachia-virus and may help in defining targets for the better implementation of Wolbachia-based strategy for disease transmission control.
HostingRepository	PRIDE
AnnounceDate	2018-03-14
AnnouncementXML	Submission_2018-03-14_01:19:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dupuy Jean-William
SpeciesList	scientific name: Aedes ; NCBI TaxID: 7158;
ModificationList	monohydroxylated residue; acetylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-10-04 01:45:17	ID requested
⏵ 1	2018-03-14 01:19:20	announced

Saucereau Y, Valiente Moro C, Dieryckx C, Dupuy JW, Tran FH, Girard V, Potier P, Mavingui P, Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-arbovirus interference phenomenon. BMC Genomics, 18(1):635(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Aedes albopictus, Wolbachia, Chikungunya virus, LC-MS, Quantitative proteomics,

Patrick Mavingui
contact affiliation	Groupe de Recherche "Dynamique microbienne et Transmission virale" UMR CNRS 5557 - Ecologie Microbienne Bâtiment Lwoff 10, rue Rafael Dubois 69100 Villeurbanne Cedex France
contact email	patrick.mavingui@cnrs.fr
lab head
Dupuy Jean-William
contact affiliation	Plateforme Proteome Bordeaux
contact email	jean-william.dupuy@u-bordeaux.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/03/PXD005091

PRIDE project URI

• PRIDE
  1. PXD005091
     1. Label: PRIDE project
     2. Name: Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-virus interference phenomenon