PXD005022

PXD005022 is an original dataset announced via ProteomeXchange.

Title	Quantitative proteomics of bloodstream infection
Description	We have performed LC-MS based plasma proteomics of twenty febrile patients coming in at Peijas Hospital, Helsinki University Hospital (Vantaa, Finland). At the same time, blood culture was performed to classify the patients to blood culture positive and negative for bloodstream infections. Blood culture negative patients served as controls for the positive ones and these two groups were used for identifying protein profile changes occurring in positive patients. We have subsequently performed various statistical analyses such as principal component analysis as well as pathway analysis by two different methods. We show, in the current study, proteins significantly differing in these two groups as well as dysregulated pathways. These changes seem not to depend on bacterial species as different patients had different blood stream infections. Further, we statistically analyzed the proteomic dataset to find the potential biomarkers which can classify the two classes of patients.
HostingRepository	PRIDE
AnnounceDate	2017-02-28
AnnouncementXML	Submission_2017-02-28_09:35:35.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sakari Joenväärä
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-22 07:29:15	ID requested
⏵ 1	2017-02-28 09:35:36	announced

Kuusela P, Saraswat M, Joenv, ä, ä, r, ä S, Kaartinen J, J, ä, rvinen A, Renkonen R, Changes in plasma protein levels as an early indication of a bloodstream infection. PLoS One, 12(2):e0172987(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: bloodstream infection, sepsis, MSE

Risto Renkonen
contact affiliation	Transplantation Laboratory, University of Helsinki & HUSLAB, Helsinki University Hospital, Helsinki, Finland.
contact email	risto.renkonen@helsinki.fi
lab head
Sakari Joenväärä
contact affiliation	Helsinki University
contact email	sakari.joenvaara@helsinki.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/02/PXD005022

PRIDE project URI

• PRIDE
  1. PXD005022
     1. Label: PRIDE project
     2. Name: Quantitative proteomics of bloodstream infection