PXD004967

PXD004967 is an original dataset announced via ProteomeXchange.

Title	Proteomic Analysis of Non-depleted Serum Proteins from a Pig and Human compared to Dolphin
Description	Targeted approaches have been widely used to help explain physiological adaptations, but few studies have used non-targeted omics approaches to explore differences between diving marine mammals and terrestrial mammals. A rank comparison of undepleted serum proteins from common bottlenose dolphins (Tursiops truncatus) and pooled normal human serum led to the discovery of 11 proteins that appeared exclusive to dolphin serum. For dolphin proteins that did not match human serum proteins, a second comparison was made with Yorkshire pig (Sus scrofa)serum proteins to determine whether phylogenetic differences in serum proteins could simply explain the differences between dolphin and human. Three out of 11 proteins that were considered unique to the dolphin high abundance serum proteome were ranked within the high abundance pig serum proteome. Compared to the comprehensive human plasma proteome, 5 of 11 serum proteins had a differential rank greater than 200. Major differences exist in the circulating blood proteome of the bottlenose dolphin compared to terrestrial mammals and exploration of these differences in bottlenose dolphins and other marine mammals may identify veiled protective strategies to counter physiological stress.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-10-26_13:42:53.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Philip Sobolesky
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-14 02:51:12	ID requested
⏵ 1	2018-10-26 13:42:54	announced

Sobolesky P, Parry C, Boxall B, Wells R, Venn-Watson S, Janech MG, Proteomic Analysis of Non-depleted Serum Proteins from Bottlenose Dolphins Uncovers a High Vanin-1 Phenotype. Sci Rep, 6():33879(2016) [pubmed]

curator keyword: Biological

submitter keyword: Sus scrofa

Tursiops truncatus

LC-MSMS

Vanin-1

Michael G Janech
contact affiliation	Medical University of South Carolina Division of Nephrology Charleston, SC 29425 USA
contact email	Janechmg@musc.edu
lab head
Philip Sobolesky
contact affiliation	Medical University of South Carolina
contact email	psobolesky@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD004967

PRIDE project URI

• PRIDE
  1. PXD004967
     1. Label: PRIDE project
     2. Name: Proteomic Analysis of Non-depleted Serum Proteins from a Pig and Human compared to Dolphin