PXD004956

PXD004956 is an original dataset announced via ProteomeXchange.

Title	Treating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Conditioned Medium]
Description	Hypoxia-related pregnancy complications increase the risk of disease in the child in later life. No prevention is available. Previously we noted that a trophoblast barrier, an in vitro model of the placenta, reacted to oxidative stress by secreting factors that damage neighbouring cells. Application of mitochondrion-targeted antioxidant MitoQ prevented this. Here we tested the effects of MitoQ-bound nanoparticles on trophoblast barriers and in a rat model of gestational hypoxia.A single dose of MitoQ-nanoparticles, administered maternally before a hypoxic episode, reduced oxidative stress in the placental barrier without reaching the fetus and prevented changes to birthweight. MitoQ-nanoparticles further suppressed damaging signalling from the placental barriers. Altered signalling molecules in the fetal plasma and in conditioned media from rat placenta included changes to proteins with relevance to cardiovascular disease. We suggest as a future possibility, treatment of the placenta to prevent disease in the offspring in later life.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:10:08.577.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hannah Scott
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-13 03:49:39	ID requested
1	2017-08-22 05:50:10	announced
2	2017-08-25 01:52:46	announced	Updated publication reference for PubMed record(s): 28831049.
⏵ 3	2024-10-22 04:10:09	announced	2024-10-22: Updated project metadata.

10.1038/s41598-017-06300-1;

Phillips TJ, Scott H, Menassa DA, Bignell AL, Sood A, Morton JS, Akagi T, Azuma K, Rogers MF, Gilmore CE, Inman GJ, Grant S, Chung Y, Aljunaidy MM, Cooke CL, Steinkraus BR, Pocklington A, Logan A, Collett GP, Kemp H, Holmans PA, Murphy MP, Fulga TA, Coney AM, Akashi M, Davidge ST, Case CP, Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Sci Rep, 7(1):9079(2017) [pubmed]

curator keyword: Biomedical

submitter keyword: Pregnancy, Placenta, Oxidative Stress, MitoQ, Fetal Development, Nanoparticles, Hypoxia

Patrick Case
contact affiliation	Foetal Exposure Group School of Clinical Sciences University of Bristol United Kingdom
contact email	C.P.Case@bristol.ac.uk
lab head
Hannah Scott
contact affiliation	University of Bristol
contact email	hs9350@my.bristol.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD004956

PRIDE project URI

• PRIDE
  1. PXD004956
     1. Label: PRIDE project
     2. Name: Treating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Conditioned Medium]