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PXD004956

PXD004956 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleTreating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Conditioned Medium]
DescriptionHypoxia-related pregnancy complications increase the risk of disease in the child in later life. No prevention is available. Previously we noted that a trophoblast barrier, an in vitro model of the placenta, reacted to oxidative stress by secreting factors that damage neighbouring cells. Application of mitochondrion-targeted antioxidant MitoQ prevented this. Here we tested the effects of MitoQ-bound nanoparticles on trophoblast barriers and in a rat model of gestational hypoxia.A single dose of MitoQ-nanoparticles, administered maternally before a hypoxic episode, reduced oxidative stress in the placental barrier without reaching the fetus and prevented changes to birthweight. MitoQ-nanoparticles further suppressed damaging signalling from the placental barriers. Altered signalling molecules in the fetal plasma and in conditioned media from rat placenta included changes to proteins with relevance to cardiovascular disease. We suggest as a future possibility, treatment of the placenta to prevent disease in the offspring in later life.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:10:08.577.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterHannah Scott
SpeciesList scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-09-13 03:49:39ID requested
12017-08-22 05:50:10announced
22017-08-25 01:52:46announcedUpdated publication reference for PubMed record(s): 28831049.
32024-10-22 04:10:09announced2024-10-22: Updated project metadata.
Publication List
10.1038/s41598-017-06300-1;
Phillips TJ, Scott H, Menassa DA, Bignell AL, Sood A, Morton JS, Akagi T, Azuma K, Rogers MF, Gilmore CE, Inman GJ, Grant S, Chung Y, Aljunaidy MM, Cooke CL, Steinkraus BR, Pocklington A, Logan A, Collett GP, Kemp H, Holmans PA, Murphy MP, Fulga TA, Coney AM, Akashi M, Davidge ST, Case CP, Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development. Sci Rep, 7(1):9079(2017) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Pregnancy, Placenta, Oxidative Stress, MitoQ, Fetal Development, Nanoparticles, Hypoxia
Contact List
Patrick Case
contact affiliationFoetal Exposure Group School of Clinical Sciences University of Bristol United Kingdom
contact emailC.P.Case@bristol.ac.uk
lab head
Hannah Scott
contact affiliationUniversity of Bristol
contact emailhs9350@my.bristol.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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