PXD004952

PXD004952 is an original dataset announced via ProteomeXchange.

Title	Ska3-microtubule interactions
Description	The Ndc 80 and Ska complex are the major microtubule-binding factors of the kinetochore responsible for maintaining chromosome-microtubule coupling during chromosome segregation. We previously showed that the Ska1 subunit of the Skacomlex binds dynamic microtubules. This project demonstrated that Ska3 subunit is required to modulate the microtubule binding capability of the Ska complex by directly interacting with tubulin monomer and indirectly by interacting with tubulin contacting regions of Ska1.
HostingRepository	PRIDE
AnnounceDate	2016-10-04
AnnouncementXML	Submission_2016-10-04_04:23:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juan Zou
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-13 02:15:32	ID requested
⏵ 1	2016-10-04 04:23:14	announced

Abad MA, Zou J, Medina-Pritchard B, Nigg EA, Rappsilber J, Santamaria A, Jeyaprakash AA, Ska3 Ensures Timely Mitotic Progression by Interacting Directly With Microtubules and Ska1 Microtubule Binding Domain. Sci Rep, 6():34042(2016) [pubmed]

curator keyword: Biological

submitter keyword: Ska complex, microtubule

Prof. Juri Rappsilber
contact affiliation	Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3BF, UK Chair of Bioanalytics, Institute of Biotechnology, Technische Universitaet, Berlin, 13355 Berlin, Germany
contact email	juri.rappsilber@ed.ac.uk
lab head
Juan Zou
contact affiliation	The University of Edinburgh
contact email	jzou@ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/10/PXD004952

PRIDE project URI

• PRIDE
  1. PXD004952
     1. Label: PRIDE project
     2. Name: Ska3-microtubule interactions