PXD004951

PXD004951 is an original dataset announced via ProteomeXchange.

Title	Maternal nutrition modulates fetal development through inducing placental efficiency changes in gilts
Description	Intra-uterine growth restriction (IUGR) and fetal overgrowth increase the risk of postnatal health. Maternal nutrition is the major intrauterine environmental factor that alters fetal weight. However, the mechanisms underlying maternal nutrition affect fetal development is not entirely clear. We developed a pig model and used isobaric tags for relative and absolute quantification (iTRAQ) to investigate alterations in the placental proteome were obtained from gilts in normal-energy-intake (Con) and high-energy-intake (HE) group, respectively.At 90 d of gestation, the heavy fetuses were found at the tubal ends and light fetuses at the cervical ends of the uterus in Con group and the heavy fetuses had higher glucose concentration than the light fetuses. However, a higher uniformity was noted in HE group. Placental promote between these two positions indicated that a total of 78 and 50 differentially expressed proteins were detected in Con and HE group, respectively. In Con group, these proteins related to lipid metabolism (HADHA, AACS, CAD), nutrient transport (GLUT, SLC27A1) and energy metabolism (NDUFV1, NDUFV2, ATP5C1). However, the differentially expressed proteins in HE group were mainly participation in transcriptional and translational regulation and intracellular vesicular transport.
HostingRepository	PRIDE
AnnounceDate	2018-10-26
AnnouncementXML	Submission_2018-10-26_13:49:21.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Che Long
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-13 02:12:30	ID requested
⏵ 1	2018-10-26 13:49:23	announced

Che L, Yang Z, Xu M, Xu S, Che L, Lin Y, Fang Z, Feng B, Li J, Chen D, Wu D, Maternal nutrition modulates fetal development by inducing placental efficiency changes in gilts. BMC Genomics, 18(1):213(2017) [pubmed]

curator keyword: Biological

submitter keyword: energy level, gilts, fetal weight, placenta, iTRAQ

De Wu
contact affiliation	Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, China
contact email	sow_nutrition@sina.com
lab head
Che Long
contact affiliation	Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, China
contact email	chelong1989@126.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD004951
     1. Label: PRIDE project
     2. Name: Maternal nutrition modulates fetal development through inducing placental efficiency changes in gilts