PXD004938

PXD004938 is an original dataset announced via ProteomeXchange.

Title	Identification of proteins interacting with GFP-GA, GR, PA, PG and PR fusion proteins
Description	Expansion of a hexanucleotide repeat GGGGCC (G4C2) in C9ORF72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Transcripts carrying (G4C2) expansions undergo unconventional, non-ATG-dependent translation, generating toxic dipeptide repeat (DPR) proteins that are thought to contribute to disease. Here, we transfected HEK 293T cells with GFP-tagged dipeptides (GA, GR, PA, PG and PR) and performed LC-MS/MS to identify immunoprecipitated interactors.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:32:23.789.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Timothy Shaw
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-09-12 03:43:08	ID requested
1	2016-10-03 03:40:11	announced
⏵ 2	2024-10-22 04:32:24	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Human, LC-MSMS, immunoprecipitated interactors

Junmin Peng
contact affiliation	Structural Biology & Developmental Neurobiology Director, St. Jude Proteomics Facility St. Jude Children's Research Hospital 262 Danny Thomas Place, Memphis, TN 38105
contact email	Junmin.Peng@STJUDE.ORG
lab head
Timothy Shaw
contact affiliation	St Jude Children's Research Hospital
contact email	tim.shaw@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/10/PXD004938

PRIDE project URI

• PRIDE
  1. PXD004938
     1. Label: PRIDE project
     2. Name: Identification of proteins interacting with GFP-GA, GR, PA, PG and PR fusion proteins