PXD004859

PXD004859 is an original dataset announced via ProteomeXchange.

Title	Anal Canal Cancer : subclassification
Description	Etiologically linked to HPV infection, malignancies of the anal canal have substantially increased in incidence over the last 20 years. Although most anal squamous cell carcinomas (SCC) respond well to chemoradiotherapy, for undetermined reasons, a subgroup of patients experience a poor outcome. Despite cumulative efforts for discovering independent predictors for overall survival, both nodal status and tumor size are still the only reliable factors predicting patient outcome. In the present study, we correlated both proteomic signatures and clinicopathological features of neoplastic lesions arising from two distinct portions of the anal canal: the lower part (squamous zone) and the more proximal anal transitional zone. Although microdissected cancer cells appeared indistinguishable by morphology (squamous phenotype), unsupervised clustering analysis of the whole proteome significantly highlighted the heterogeneity that exists within anal canal tumors. More importantly, two region-specific subtypes of SCC were revealed. The expression profile (sensitivity/specificity) of several selected biomarkers (keratin filaments) further confirmed the subclassification of anal (pre)cancers based on their cellular origin. Less commonly detected compared to their counterparts located in the squamous mucosa, SCC originating in the transitional zone displayed more frequently a poor or basaloid differentiation and were significantly correlated with reduced disease-free and overall survivals. Taken together, we present for the first time direct evidence that anal canal SCC comprises two distinct entities with different cells of origin, proteomic signatures and survival rates. This study forms the basis for a novel dualistic classification of anal carcinoma with implications for management, outcome expectations and possibly therapeutic approaches.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:31:55.381.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nicolas Smargiasso
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-08-18 01:32:27	ID requested
1	2016-12-20 13:40:50	announced
2	2017-10-24 03:09:57	announced	Updated project metadata.
⏵ 3	2024-10-22 04:32:00	announced	2024-10-22: Updated project metadata.

10.1002/path.4858;

Herfs M, Longuesp, é, e R, Quick CM, Roncarati P, Suarez-Carmona M, Hubert P, Lebeau A, Bruyere D, Mazzucchelli G, Smargiasso N, Baiwir D, Lai K, Dunn A, Obregon F, Yang EJ, Pauw E, Crum CP, Delvenne P, Proteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma. J Pathol, 241(4):522-533(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: transitionnal zone, Anal,HPV

Philippe Delvenne
contact affiliation	Head of Department (Pathology), University of Liege, Liege, Belgium
contact email	p.delvenne@ulg.ac.be
lab head
Nicolas Smargiasso
contact affiliation	University of Liege
contact email	nsmargiasso@ulg.ac.be
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD004859

PRIDE project URI

• PRIDE
  1. PXD004859
     1. Label: PRIDE project
     2. Name: Anal Canal Cancer : subclassification