PXD004818 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Spectral histopathology supported laser capture microdissection and quantitative proteome analysis of diffuse malignant mesothelioma |
Description | FTIR based spectral histopathology was used for label-free classification of tumor tissue sections. The regions of interest were identified and annotated with high spatial resolution. The spatial information was used for automated laser capture microdissection of relevant tissue areas. Subsequently, the collected tissue samples were analyzed using quantitative proteomics. This novel approach for precise sample collection in clinical studies was applied to differentiate epitheloid and sarcomatoid subtypes of diffuse malignant mesothelioma. |
HostingRepository | PRIDE |
AnnounceDate | 2017-03-31 |
AnnouncementXML | Submission_2017-03-31_04:27:30.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD004818 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Thilo Bracht |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | residues isobaric at 128.058578 Da; Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-08-16 01:21:59 | ID requested | |
⏵ 1 | 2017-03-31 04:27:31 | announced | |
Publication List
Gro, ß, erueschkamp F, Bracht T, Diehl HC, Kuepper C, Ahrens M, Kallenbach-Thieltges A, Mosig A, Eisenacher M, Marcus K, Behrens T, Br, ü, ning T, Theegarten D, Sitek B, Gerwert K, Spatial and molecular resolution of diffuse malignant mesothelioma heterogeneity by integrating label-free FTIR imaging, laser capture microdissection and proteomics. Sci Rep, 7():44829(2017) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Colorectal carcinoma, diffuse malignant mesothelioma, laser capture microdissection, infrared spectral histopathology, FTIR |
Contact List
Barbara Sitek |
contact affiliation | Ruhr-Universität Bochum Medizinisches Proteom-Center AG Clinical Proteomics |
contact email | barbara.sitek@rub.de |
lab head | |
Thilo Bracht |
contact affiliation | Clinical Proteomics |
contact email | thilo.bracht@rub.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/03/PXD004818 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004818
- Label: PRIDE project
- Name: Spectral histopathology supported laser capture microdissection and quantitative proteome analysis of diffuse malignant mesothelioma