PXD004812

PXD004812 is an original dataset announced via ProteomeXchange.

Title	Protein profiling of 6-OHDA induced PD Model treated by TBN
Description	Parkinson's disease (PD) listed as the second most common neurodegenerative disease. 2-[[(1,1-Dimethylethyl)oxidoimino]-methyl]-3,5,6-trimethylpyrazine (TBN), a novel nitrone derivative of tetramethylpyrazine, has shown benefits for the treatment both in vitro and in vivo, TBN protects and rescues dopaminergic neurons from MPP(+) and MPTP/6-OHDA-induced damage by reducing ROS and increasing cellular antioxidative defense capability. Here, we investigate the proteome changes in the 6-OHDA induced PD rat model and the rescue effects after treated by TBN.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:48:50.587.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Ge
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-08-15 06:56:49	ID requested
1	2022-03-02 03:07:17	announced
⏵ 2	2023-11-14 08:48:51	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: TBN,Rat Model,6-OHDA, Parkinson's disease

Wei Ge
contact affiliation	Insitute of Basic Medical Sciences, Chinese Academy of Medical Sciences
contact email	Wei.ge@chem.ox.ac.uk
lab head
Wei Ge
contact affiliation	National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
contact email	wei.ge@chem.ox.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD004812
     1. Label: PRIDE project
     2. Name: Protein profiling of 6-OHDA induced PD Model treated by TBN