PXD004741

PXD004741 is an original dataset announced via ProteomeXchange.

Title	Mouse ciliopathy-associated CPLANE proteins
Description	Combining proteomics, in vivo imaging and genetic analysis of proteins linked to planar cell polarity (Inturned, Fuzzy and Wdpcp), we identified and characterized a new genetic module, which we term CPLANE (ciliogenesis and planar polarity effector), and an extensive associated protein network. CPLANE proteins physically and functionally interact with the poorly understood ciliopathy-associated protein Jbts17 at basal bodies, where they act to recruit a specific subset of IFT-A proteins. In the absence of CPLANE, defective IFT-A particles enter the axoneme and IFT-B trafficking is severely perturbed. Accordingly, mutation of CPLANE genes elicits specific ciliopathy phenotypes in mouse models and is associated with ciliopathies in human patients.
HostingRepository	PRIDE
AnnounceDate	2017-01-17
AnnouncementXML	Submission_2017-01-17_07:31:15.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD004741
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Janos Demeter
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Phospho; Propionamide; Glu->pyro-Glu; Deamidated; Methyl; Oxidation; Acetyl; GlyGly; Gln->pyro-Glu
Instrument	LTQ Orbitrap Velos; LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2016-08-09 02:59:17	ID requested
1	2016-08-15 03:59:36	announced
⏵ 2	2017-01-17 07:31:16	announced	Updated project metadata.

Toriyama M, Lee C, Taylor SP, Duran I, Cohn DH, Bruel AL, Tabler JM, Drew K, Kelly MR, Kim S, Park TJ, Braun DA, Pierquin G, Biver A, Wagner K, Malfroot A, Panigrahi I, Franco B, Al-Lami HA, Yeung Y, Choi YJ, Duffourd Y, Faivre L, Rivi, è, re JB, Chen J, Liu KJ, Marcotte EM, Hildebrandt F, Thauvin-Robinet C, Krakow D, Jackson PK, Wallingford JB, The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery. Nat Genet, 48(6):648-56(2016) [pubmed]

curator keyword: Biological

submitter keyword: Mouse, ciliopathy, CPLANE, "Planar Cell Polarity”, “Human Genetics"

Peter K. Jackson
contact affiliation	Baxter Laboratory for Stem Cell Biology Department of Microbiology & Immunology Stanford University School of Medicine 269 Campus Drive CCSR 3205b Stanford, CA 94305-5175
contact email	pjackson@stanford.edu
lab head
Janos Demeter
contact affiliation	Stanford University
contact email	jdemeter@stanford.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD004741
     1. Label: PRIDE project
     2. Name: Mouse ciliopathy-associated CPLANE proteins