PXD004740

PXD004740 is an original dataset announced via ProteomeXchange.

Title	Early prediction of inflammation by unprecedented unbiased linking of tissue ‎molecular ‎composition and structure
Description	The identification of molecular signatures that aid early diagnosis of complex tissue pathologies, ‎such as inflammatory diseases, ‎poses a major scientific and clinical challenge due to their genetic ‎and phenotypic heterogeneity. We have been able to unprecedentedly discover a distinct tissue ‎state occurring before the onset of inflammatory clinical symptoms by integrating quantitative ‎proteomics with advanced microscopy analyses. Through monitoring colonic extracellular matrix ‎‎(ECM) ‎remodeling in colitis animal models we have unexpectedly revealed that pre-‎symptomatic ‎tissues display a unique ECM signature in terms of molecular ‎composition, morphology and ‎stiffness. By applying‏ ‏advanced computational analyses we were able to project quantitative ‎proteomics data onto an axis correlating with spatially resolved tissue damage originating from ‎the ECM. These results bridge the gap between tissue structure and composition while outlining ‎the predictive ‎power of the cellular microenvironment in early diagnostics of ‎inflammatory ‎diseases. ‎
HostingRepository	PRIDE
AnnounceDate	2020-12-01
AnnouncementXML	Submission_2020-11-30_23:27:12.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Geiger
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-08-09 02:32:22	ID requested
⏵ 1	2020-11-30 23:27:13	announced

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: inflammatory bowel disease .proteomics,colitis,extracellular matrix

Dr. Tamar Geiger
contact affiliation	Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University Israel
contact email	geiger@tauex.tau.ac.il
lab head
Tamar Geiger
contact affiliation	Tel Aviv University
contact email	geiger@tauex.tau.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/12/PXD004740

PRIDE project URI

• PRIDE
  1. PXD004740
     1. Label: PRIDE project
     2. Name: Early prediction of inflammation by unprecedented unbiased linking of tissue ‎molecular ‎composition and structure