PXD004671

PXD004671 is an original dataset announced via ProteomeXchange.

Title	A Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue
Description	Obesity and type-2 diabetes are associated with tissue-inflammation and metabolic defects in fat depots. Foxp3+regulatory T(Treg) cells mediate T-cell tolerance, thereby controlling tissue inflammation. However, the molecular underpinnings how environmental stimuli interlink T-cell tolerance with adipose tissue function remain largely unknown. Here, we report that cold exposure or beta3-adrenergic receptor (ADRB3) stimulation induces T-cell tolerance in vitro and in murine and humanized models. Tolerance induction was verified by CD4+T-cell-proteomes revealing higher protein expression of Foxp3 regulatory networks. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated by either ADRB3-stimulation or cold-exposure, and therefore might enhance Treg induction. By loss and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T-cell-specific Stat6/Pten axis links cold-exposure or ADRB3 stimulation with Foxp3+Treg induction and adipose tissue function. Our findings open new avenues in understanding tissue-specific T-cell tolerance and the design of precision concepts toward personalized immune-metabolic health.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:35:39.770.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-28 02:45:29	ID requested
1	2017-09-11 02:09:58	announced
⏵ 2	2024-10-22 04:35:47	announced	2024-10-22: Updated project metadata.

10.1016/j.cmet.2017.08.008;

K, ä, lin S, Becker M, Ott VB, Serr I, Hosp F, Mollah MMH, Keipert S, Lamp D, Rohner-Jeanrenaud F, Flynn VK, Scherm MG, Nascimento LFR, Gerlach K, Popp V, Dietzen S, Bopp T, Krishnamurthy P, Kaplan MH, Serrano M, Woods SC, Tripal P, Palmisano R, Jastroch M, Bl, ü, her M, Wolfrum C, Weigmann B, Ziegler AG, Mann M, Tsch, ö, p MH, Daniel C, A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab, 26(3):475-492.e7(2017) [pubmed]

submitter keyword: T cell tolerance, Foxp3, cold exposure

Carolin Daniel
contact affiliation	Helmholtz Zentrum München German Research Center for Environmental Health Institute of Diabetes Research Group Immune Tolerance in Diabetes Heidemannstraße 1 80939 München
contact email	carolin.daniel@helmholtz-muenchen.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/09/PXD004671

PRIDE project URI

• PRIDE
  1. PXD004671
     1. Label: PRIDE project
     2. Name: A Stat6/Pten axis links cold exposure with T cell tolerance in adipose tissue