PXD004658

PXD004658 is an original dataset announced via ProteomeXchange.

Title	Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates
Description	Cancer metastasis causes approximately 90% of all cancer-related death. Independent of the advancement of cancer therapy, a majority of late stage patients suffers from metastatic cancer. Metastasis progresses by cancer cell migration and invasion throughout the body. This migration of cancer cells requires the formation of pseudopodia in the direction of movement, but detailed understanding of the process and accordingly strategies of prevention remain elusive. Here, we use quantitative proteomic profiling of human cancer pseudopodia to examine this mechanisms essential to metastasis formation, and identify potential candidates for pharmacological interference with the process. We demonstrate that Prohibitins (PHBs) are significantly enriched in the pseudopodia fraction derived from cancer cells, and knockdown of PHBs, as well as their chemical inhibition through Rocaglamide (Roc-A), efficiently reduces cancer cell migration.
HostingRepository	PRIDE
AnnounceDate	2021-10-29
AnnouncementXML	Submission_2021-10-29_04:34:37.369.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Johannes Graumann
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-26 07:59:15	ID requested
1	2018-04-12 02:38:47	announced
2	2018-04-16 01:39:04	announced	Updated publication reference for PubMed record(s): 29643415.
⏵ 3	2021-10-29 04:34:38	announced	2021-10-29: Updated project metadata.

Choi S, Bhagwat AM, Al Mismar R, Goswami N, Ben Hamidane H, Sun L, Graumann J, Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates. Sci Rep, 8(1):5858(2018) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: breast cancer

metastasis

migration

pseudopodia

proteomics

Johannes Graumann
contact affiliation	Weill Cornell Medicine - Qatar
contact email	jog2030@qatar-med.cornell.edu
lab head
Johannes Graumann
contact affiliation	Max Planck Institute for Heart and Lung Research
contact email	johannes.graumann@mpi-bn.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/04/PXD004658

PRIDE project URI

• PRIDE
  1. PXD004658
     1. Label: PRIDE project
     2. Name: Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates