PXD004647

PXD004647 is an original dataset announced via ProteomeXchange.

Title	Human Tankyrases TAP-LC-MSMS
Description	Tankyrase 1 (TNKS1) and tankyrase 2 (TNKS2) belong to the poly(ADP-ribose) polymerase (PARP) family of proteins, which use NAD+ to modify substrate proteins with ADP-ribose modifications. Tankyrases are implicated involving in multiple cellular functions, including the telomere length control, Wnt/b-catenin pathway regulation, glucose uptake and cell cycle regulation. Emerging evidences reveal the pathological relevance of tankyrase in diseases and propose these two key enzymes as potential drug targets. However, the cellular functions and regulatory machineries of tankyrases are still largely unknown. Through this proteomic analysis, we not only defined the protein-protein interaction map for the tankyrases which revealed 100~150 high confident interacting proteins for tankyrases in various cellular functions, but also uncovered the novel regulating function of tankyrase in peroxisome homeostasis.
HostingRepository	PRIDE
AnnounceDate	2017-07-24
AnnouncementXML	Submission_2017-07-25_01:01:14.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD004647
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Xu Li
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-25 02:05:14	ID requested
⏵ 1	2017-07-25 01:01:15	announced

Li X, Han H, Zhou MT, Yang B, Ta AP, Li N, Chen J, Wang W, Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Rep, 20(3):737-749(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Human, Tankyrase, TAP, LC-MSMS

Junjie Chen
contact affiliation	Experimental Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA
contact email	jchen8@mdanderson.org
lab head
Xu Li
contact affiliation	Experimental Radiation Oncology
contact email	xulimda@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/07/PXD004647

PRIDE project URI

• PRIDE
  1. PXD004647
     1. Label: PRIDE project
     2. Name: Human Tankyrases TAP-LC-MSMS