PXD004591

PXD004591 is an original dataset announced via ProteomeXchange.

Title	Integration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome
Description	Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over-produced in the most lethal form of ovarian cancer, called high grade serous ovarian cancer (HGSOC). To determine its underlying molecular mechanism of action, a comprehensive analysis of KLK7 degradome in the OVMZ-6 cell-secreted proteins was performed using two complementary proteomic approaches, quantitative PROtein Topography and Migration Analysis Platform (qPROTOMAP) and Terminal Amine Isotopic Labelling of Substrates (TAILS).
HostingRepository	PRIDE
AnnounceDate	2019-02-15
AnnouncementXML	Submission_2019-02-15_07:39:17.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD004591
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Lakmali Munasinghage Silva
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	6x(13)C labeled residue; monohydroxylated residue; acetylated residue; formylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-18 03:17:13	ID requested
⏵ 1	2019-02-15 07:39:18	announced

Silva LM, Kryza T, Stoll T, Hoogland C, Dong Y, Stephens CR, Hastie ML, Magdolen V, Kleifeld O, Gorman JJ, Clements JA, Integration of Two In-depth Quantitative Proteomics Approaches Determines the Kallikrein-related Peptidase 7 (KLK7) Degradome in Ovarian Cancer Cell Secretome. Mol Cell Proteomics, 18(5):818-836(2019) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Degradome, extracellular, high-grade serous, kallikrein-related peptidase, matrix metalloprotease, microenvironment, omics, ovarian cancer, protease, substrate, thrombospondin, transcriptome, tumour

D. Prof Judith Ann Clements
contact affiliation	NHMRC Principal Research Fellow | Institute of Health and Biomedical Innovation | Queensland University of Technology at the Translational Research Institute Leader, Kallikrein Protease & Tumour Microenvironment Group| Scientific Director, Australian Prostate Cancer Research Centre-Queensland
contact email	j.clements@qut.edu.au
lab head
Lakmali Munasinghage Silva
contact affiliation	Queensland University of Technology, Institute of Health and Biomedical Innovation at the Translational Research Institute
contact email	munasinghage.silva@qut.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/02/PXD004591

PRIDE project URI

• PRIDE
  1. PXD004591
     1. Label: PRIDE project
     2. Name: Integration of two in-depth proteomics approaches determines the high grade serous ovarian cancer-associated kallikrein-related peptidase 7 (KLK7) degradome