PXD004588 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | ZIKV infection of human neurospheres |
Description | Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_03:58:28.397.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Caroline Teles |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Synapt MS |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2016-07-18 01:54:58 | ID requested | |
1 | 2018-10-26 15:27:39 | announced | |
⏵ 2 | 2024-10-22 03:58:29 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1038/srep40780; |
Garcez PP, Nascimento JM, de Vasconcelos JM, Madeiro da Costa R, Delvecchio R, Trindade P, Loiola EC, Higa LM, Cassoli JS, Vit, ó, ria G, Sequeira PC, Sochacki J, Aguiar RS, Fuzii HT, de Filippis AM, da Silva Gon, ç, alves Vianez J, ú, nior JL, Tanuri A, Martins-de-Souza D, Rehen SK, Zika virus disrupts molecular fingerprinting of human neurospheres. Sci Rep, 7():40780(2017) [pubmed] |
Keyword List
submitter keyword: microcephaly, iPSC,human, zika |
Contact List
Daniel Martins-de-Souza |
contact affiliation | Lab of Neuroproteomics, Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil ( lab head ) |
contact email | dams90@gmail.com |
lab head | |
Caroline Teles |
contact affiliation | University of Campinas |
contact email | carolbr.teles@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD004588
- Label: PRIDE project
- Name: ZIKV infection of human neurospheres