PXD004584

PXD004584 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Age-related changes in protein abundance in nematodes
Description	Using quantitative mass spectrometry together with protein and peptide-level fractionation, we can now report a major increase in coverage of the C. elegans proteome, identifying over 9,300 proteins in three biological replicates. The resulting data have been assembled into a searchable, online resource with a user-friendly graphical interface to provide convenient and open access to the community (https://www.peptracker.com/epd/). By quantifying these proteins in fertile, post-reproductive and aging animals, we show that there is a striking change in abundance of ~8% of the proteome during the course of aging. Network analysis of our proteomics data reveals a concerted down-regulation of proteins involved in fatty acid, amino acid and carbohydrate metabolism, as well as peroxisome function, with increasing age.
HostingRepository	MassIVE
AnnounceDate	2016-07-15
AnnouncementXML	Submission_2016-07-15_16:56:50.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vikram Narayan
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-15 16:56:48	ID requested
⏵ 1	2016-07-15 16:56:50	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: Aging, C elegans, Proteomics, SILAC, Peroxisome, Metabolism, daf-2

submitter keyword: Aging, C elegans, Proteomics, SILAC, Peroxisome, Metabolism, daf-2

Contact List

Angus Lamond
lab head
Vikram Narayan
contact affiliation	University of Dundee
contact email	vikram.narayan@gmail.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000079263

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000079263