PXD004558

PXD004558 is an original dataset announced via ProteomeXchange.

Title	SWATH-MS Analysis of Striatal Synaptic Mitochondria from Pink1 KO rats
Description	This study investigates the proteomic alterations in striatal synaptic mitochondria isolated from 3-month-old wild-type and Pink1 KO rats using the SWATH-MS strategy. This dataset consists of 32 raw MS files, comprising 8 DIA (SWATH) and 24 DDA runs on a TripleTOF 5600 (SCIEX). Our findings revealed synaptic mitochondrial proteomic changes due to loss of Pink1.
HostingRepository	PRIDE
AnnounceDate	2016-09-28
AnnouncementXML	Submission_2016-09-28_01:14:50.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kelly Stauch
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-12 01:55:55	ID requested
⏵ 1	2016-09-28 01:14:52	announced

Stauch KL, Villeneuve LM, Purnell PR, Ottemann BM, Emanuel K, Fox HS, Loss of Pink1 modulates synaptic mitochondrial bioenergetics in the rat striatum prior to motor symptoms: concomitant complex I respiratory defects and increased complex II-mediated respiration. Proteomics Clin Appl, 10(12):1205-1217(2016) [pubmed]

curator keyword: Biological

submitter keyword: SWATH-MS, mitochondria, Parkinson's disease

Howard S Fox
contact affiliation	University of Nebraska Medical Center
contact email	hfox@unmc.edu
lab head
Kelly Stauch
contact affiliation	University of Nebraska Medical Center
contact email	kelly.stauch@unmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/09/PXD004558

PRIDE project URI

• PRIDE
  1. PXD004558
     1. Label: PRIDE project
     2. Name: SWATH-MS Analysis of Striatal Synaptic Mitochondria from Pink1 KO rats