PXD004439

PXD004439 is an original dataset announced via ProteomeXchange.

Title	Time-course global proteome analyses in the APPNL-F mouse model of Alzheimer disease
Description	A hallmark of Alzheimer Disease is the accumulation of aggregation-prone amyloid beta peptides, which can assemble into smaller aggregates and deposit in the form of amyloid plaques. Here we used the recently introduced APPNL-F mouse model of Alzheimer Disease, which faithfully recapitulates the amyloid beta pathology of the disease, to identify early changes to the global proteome. Using a workflow that interrogated the brain proteome of these mice by quantitative mass spectrometry at five, ten and fifteen months of age.
HostingRepository	PRIDE
AnnounceDate	2017-08-02
AnnouncementXML	Submission_2019-02-12_08:09:40.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Declan Williams
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; S-pyridylethyl-L-cysteine; phosphorylated residue; monohydroxylated residue; deamidated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2016-06-24 04:23:28	ID requested
1	2017-08-02 09:56:20	announced
⏵ 2	2019-02-12 08:09:43	announced	Updated publication reference for PubMed record(s): 28832675.

Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G, burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease. PLoS One, 12(8):e0182844(2017) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: mouse, brain, amyloid beta, LC-MS/MS

Gerold Schmitt-Ulms
contact affiliation	Tanz Centre for Research in Neurodegenerative Diseases, Faculty of Medicine, University of Toronto
contact email	g.schmittulms@utoronto.ca
lab head
Declan Williams
contact affiliation	University of Toronto
contact email	gwillym.williams@utoronto.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/08/PXD004439

PRIDE project URI

• PRIDE
  1. PXD004439
     1. Label: PRIDE project
     2. Name: Time-course global proteome analyses in the APPNL-F mouse model of Alzheimer disease