PXD004390
PXD004390 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Unconventional Endosome-Like Compartment and Retromer Complex (Sangare et al., 2016) |
| Description | Membrane trafficking pathways play critical roles in Apicomplexa, a phylum of protozoan parasites that cause life-threatening diseases worldwide. Here, we report the first retromer-trafficking interactome in Toxoplasma gondii. This retromer complex is typified by a singular architecture with a trimer Vps35-Vps26-Vps29 core complex that serves as a hub for the known endosome-like compartment (ELC) and parasite-specific proteins. Conditional ablation of TgVps35 revealed that the retromer complex is not only crucial for the biogenesis of secretory organelles, but also for maintaining parasite architecture. The aim of this quantitative experiment was to determine the stoichiometry the trimer involved in the retrograde transport of Toxoplasma gondii. |
| HostingRepository | PeptideAtlas |
| AnnounceDate | 2016-06-20 |
| AnnouncementXML | Submission_2016-06-20_15:36:51.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Benoît Westermann |
| SpeciesList | scientific name: Toxoplasma gondii; |
| ModificationList | 6x(13)C,4x(15)N labeled L-arginine; 6x(13)C,2x(15)N labeled L-lysine |
| Instrument | 6490 Triple Quadrupole LC/MS |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2016-06-20 15:29:50 | ID requested | |
| ⏵ 1 | 2016-06-20 15:36:53 | announced |
Publication List
| Sangar, é LO, Alayi TD, Westermann B, Hovasse A, Sindikubwabo F, Callebaut I, Werkmeister E, Lafont F, Slomianny C, Hakimi MA, Van Dorsselaer A, Schaeffer-Reiss C, Tomavo S, Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection. Nat Commun, 7():11191(2016) [pubmed] |
Keyword List
| curator keyword: selected reaction monitoring, SRM, targeted |
Contact List
| Benoît Westermann | |
|---|---|
| contact affiliation | CNRS UMR 7178 IPHC-DSA-LSMBO |
| contact email | benoit.westermann@etu.unistra.fr |
| dataset submitter | |
| CIANFERANI | |
| contact affiliation | CNRS UMR 7178 IPHC-DSA-LSMBO |
| contact email | sarah.cianferani@unistra.fr |
| lab head | |
Full Dataset Link List
| PeptideAtlas dataset URI |
| PASSEL experiment URI |
| PASSEL transition group browser URI |
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