PXD004378

PXD004378 is an original dataset announced via ProteomeXchange.

Title	SRM-based proteomics method to study iron metabolism of Synechocystis sp. PCC 6803
Description	During infection, host-derived lipid components present the major carbon source at the infection site. β-Oxidation of fatty acids results in the formation of acetyl-CoA. In this study, we demonstrate that consumption of fatty acids by Mycobacterium tuberculosis activates an overflow mechanism, causing the pathogen to release excess carbon intermediates as acetate. The Pta-AckA pathway mediating acetate formation proved to be reversible, enabling M. tuberculosis to reutilize the previously secreted acetate as a carbon substrate for metabolism.
HostingRepository	PeptideAtlas
AnnounceDate	2016-06-20
AnnouncementXML	Submission_2016-06-20_14:46:37.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Dorota Muth-Pawlak
SpeciesList	scientific name: Synechocystis sp. PCC 6803; NCBI TaxID: 1148;
ModificationList	No PTMs are included in the dataset
Instrument	TSQ Vantage

Revision	Datetime	Status	ChangeLog Entry
0	2016-06-20 14:43:33	ID requested
⏵ 1	2016-06-20 14:46:38	announced

R, ü, cker N, Billig S, B, ü, cker R, Jahn D, Wittmann C, Bange FC, Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability. J Bacteriol, 197(19):3182-90(2015) [pubmed]

curator keyword: selected reaction monitoring, SRM, targeted

Dorota Muth-Pawlak
contact affiliation	University of Turku
contact email	dokrmu@utu.fi
dataset submitter
Eva-Mari Aro
contact affiliation	University of Turku
contact email	evaaro@utu.fi
lab head

PeptideAtlas dataset URI

PASSEL experiment URI

PASSEL transition group browser URI